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Testing Status of Dimethylvinyl chloride (DMVC) 10623-T

 

CASRN: 513-37-1

Formula: C4-H7-Cl

Synonyms/Common Names

  • 1-Chloro-2-methyl-1-propene
  • DMVC

Short-Term Toxicity

  • 14-Day (Gavage)  (C54819A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C54819A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 63, 750 MG/KG/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C54819A)  Completed 
    • TR-316 (NIH Number: 86-2572)  (Peer Review Approval 12/09/1985A )
      Toxicology and Carcinogenesis Studies of Dimethylvinyl Chloride (1-Chloro-2-Methylpropene) (CASRN 513-37-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Clear Evidence 
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 
    • Dose: 0, 100, 200 MG/KG/50 PER GROUP.
  • 2-Year (Gavage)  (C54819A)  Completed 
    • TR-316 (NIH Number: 86-2572)  (Peer Review Approval 12/09/1985A )
      Toxicology and Carcinogenesis Studies of Dimethylvinyl Chloride (1-Chloro-2-Methylpropene) (CASRN 513-37-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Clear Evidence 
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 
    • Dose: 0, 100, 200 MG/KG/50 PER GROUP.

Special Studies

  • Absorption Distribution Metabolism Excretion (Gavage)  (S0066)  Completed 
    • Citation: Ghanayem BI, Burka LT. Comparative metabolism and disposition of 1-chloro-and 3-chloro-2-methylpropene in rats and mice. Drug Metabol Dispos. 1987 Jan-Feb;15(1):91-6.Pubmed Abstract
    • Male Rats: F344/N; Male Mice: B6C3F1
    • Dose: 150 mg/kg [R,M].
  • Cell Proliferation (Gavage)  (S0761)  Completed 
    • Citation: Ghanayem BI, Maronpot RR, Matthews HB. Association of chemically induced forestomach cell proliferation and carcinogenesis. Cancer Lett. 1986 Sep;32(3):271-8.Pubmed Abstract
    • Male Rats: F344/N
  • Metabolism (Dosed-Feed)  (S0750)  Completed 
    • Citation: Srinivas P, Burka LT. Metabolism of 1-chloro-2-methylpropene. Evidence for reactive chloroaldehyde intermediates. Drug Metab Dispos. 1988 May-Jun;16(3):449-54.Pubmed Abstract
    • Rats: F344/N

Genetic Toxicology

  • Drosophila  (758308)  Completed 
    • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63
    • Sex-Linked Recessive Lethal Positive 
    • Reciprocal Translocation Positive 
  • In Vitro Cytogenetics (CA/SCE)  (154330)  Completed 
    • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Micronucleus  (A35968)  Completed 
    • Rats: Fischer 344
    • Male Positive 
  • Micronucleus  (A50288)  Completed 
    • Mice: B6C3F1
    • Male Positive 
  • Mouse Lymphoma  (452004)  Completed 
    • Citation: Myhr B.C., McGregor, D., Bowers, L., Riach, C., Brown, A., Edwards, I., McBride, D., Martin, R., and Caspary, W.J. L5178Y mouse lymphoma cell mutation assay results with 41 compounds. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 138-167
    • Mice
    •  Positive 
  • Salmonella  (327442)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    • Citation: Zeiger, E. Mutagenicity of 42 chemicals in Salmonella Environ. Molec. Mutagen. Vol. 16(Suppl 18) (1990) 32-54
    •  Negative 
  • Salmonella  (397636)  Completed 
    • Citation: Zeiger, E. Mutagenicity of 42 chemicals in Salmonella Environ. Molec. Mutagen. Vol. 16(Suppl 18) (1990) 32-54
    •  Positive