Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of 2,6-Dichloro-p-phenylenediamine 10647-A

 

CASRN: 609-20-1

Formula: C6-H6-Cl2-N2

Synonyms/Common Names

  • 2,6-Dichloro-1,4-benzenediamine

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C50260)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C50260)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 1000, 8000 PPM/24 PER GROUP, M: 0, 625, 7500 PPM/10 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C50260)  Completed 
    • TR-219 (NIH Number: 82-1775)  (Peer Review Approval 10/15/1980A )
      Carcinogenesis Bioassay of 2,6-Dichloro-p-Phenylenediamine (CASRN 609-20-1) in F344 Rats and B6C3F1 Mice (Feed Study)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Positive 
      • Female Mice Positive 
    • Dose: FR: 0, 2000, 6000, MR: 0, 1000, 2000, M: 0, 1000, 3000 PPM/50 PER GROUP.

Special Studies

  • Absorption Distribution Metabolism Excretion (Gavage; Intravenous; Gavage; Intravenous)  (S0158)  Completed 
    • Male and Female Rats; Mice
    • Dose: 60, 600 micromol/kg [R,M]. 600 micromol/kg [R,M].

Genetic Toxicology

  • Chromosome Aberrations  (479181)  Completed 
    • Citation: Shelby, M.D. and Witt, K.L. Comparision of Results from Mouse Bone Marrow Chromosome Aberration and Micronucleus Test 25 (1995) Vol. 25, 1995 302-313
    • Mice
    •  Positive 
  • Drosophila  (976516)  Completed 
    • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • In Vitro Cytogenetics (CA/SCE)  (402554)  Completed 
    • Citation: Gulati, D., Witt, K., Anderson, B., Zeiger, E.,and Shelby, M. Chromosome aberration and sister chromatid exchange test in Chinese hamster ovary cells in vitro III: Results with 27 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 133-193
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Micronucleus  (538041)  Completed 
    • Citation: Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179
    • Mice: B6C3F1
    • Male Negative 
  • Mouse Lymphoma  (789062)  Completed 
    • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
    • Mice
    •  Positive 
  • Salmonella  (010183)  Completed 
    •  Positive 
  • Salmonella  (949384)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Positive 
  • Sister Chromatid Exchanges  (479181)  Completed 
    • Citation: Shelby, M.D. and Witt, K.L. Comparision of Results from Mouse Bone Marrow Chromosome Aberration and Micronucleus Test 25 (1995) Vol. 25, 1995 302-313
    • Mice
    • Sister Chromatid  Positive