Testing Status of Dimethyl hydrogen phosphite 10663-A
CASRN: 868-85-9
Formula: C2-H7-O3-P
Synonyms/Common Names
- Phosphonic acid, dimethyl ester
Short-Term Toxicity
- 14-Day (Gavage)
(C54773)
Completed
- Rats: F344/N; Mice: B6C3F1
- 13-Week (Gavage)
(C54773)
Completed
- Rats: F344/N; Mice: B6C3F1
- Dose: R: 0, 25, 400, M: 0, 95, 1500 MG/KG/10 PER GROUP.
Long-Term Carcinogenicity
- 2-Year (Gavage)
(C54773)
Completed
- TR-287 (NIH Number: 86-2543)
(Peer Review Approval 07/27/1984A )
Toxicology and Carcinogenesis Studies of Dimethyl Hydrogen Phosphite (CASRN 868-85-9) in F344/N Rats and B6C3F1 Mice (Gavage Studies) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Clear Evidence
- Female Rats Equivocal Evidence
- Male Mice No Evidence
- Female Mice No Evidence
- Dose: MR&M: 0, 100, 200, FR: 0, 50, 100 MG/KG/50 PER GROUP.
- TR-287 (NIH Number: 86-2543)
(Peer Review Approval 07/27/1984A )
Special Studies
- Absorption Distribution Metabolism Excretion (Intravenous; Gavage)
(S0081)
Completed
- Citation: Nomeir AA, Uraih LC. Pathological and biochemical effects of dimethyl hydrogen phosphite in Fischer 344 rats. Fundam Appl Toxicol. 1988 Jan;10(1):114-24.Pubmed Abstract
- Male Rats: F344/N; Male Rats
- Dose: 1000 mg/kg. 200, 1000 mg/kg.
- Mechanisms (in-vitro)
(S0502)
Completed
- Citation: Nomeir AA, Burka LT, Matthews HB. Analysis of dimethyl hydrogen phosphite and its stability under simulated physiological conditions. J Anal Toxicol. 1988 Nov-Dec;12(6):334-8.Pubmed Abstract
Genetic Toxicology
- Chromosome Aberrations
(515672)
Completed
- Mice
- Positive (Nonstandard Protocol)
- Drosophila
(292004)
Completed
- Citation: Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702
- Reciprocal Translocation/Sex-Linked Recessive Lethal Negative
- In Vitro Cytogenetics (CA/SCE)
(601658)
Completed
- Citation: Gulati, D., Witt, K., Anderson, B., Zeiger, E.,and Shelby, M. Chromosome aberration and sister chromatid exchange test in Chinese hamster ovary cells in vitro III: Results with 27 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 133-193
- Sister Chromatid Exchange Positive
- Chromosome Aberrations Positive
- Micronucleus
(224367)
Completed
- Citation: Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179
- Mice: B6C3F1
- Male Positive
- Mouse Lymphoma
(199344)
Completed
- Citation: McGregor, D.B., Brown, A., Cattanach, P., Edwards, I., McBride, D., and Caspary, W.J. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay to coded chemicals. II. 18 coded chemicals. Environ. Molec. Mutagen. Vol. 11 (1988) 91-118
- Mice
- Positive
- Salmonella
(772334)
Completed
- Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
- Equivocal
- Salmonella
(940869)
Completed
- Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
- Weakly Positive
- Sister Chromatid Exchanges
(515672)
Completed
- Mice
- Sister Chromatid Positive (Nonstandard Protocol)