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Testing Status of Dimethyl hydrogen phosphite 10663-A

CASRN: 868-85-9

Formula: C2-H7-O3-P

Synonyms/Common Names

  • Phosphonic acid, dimethyl ester

Short-Term Toxicity

  • 14-Day (Gavage)  (C54773)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C54773)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 25, 400, M: 0, 95, 1500 MG/KG/10 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Gavage)  (C54773)  Completed 
    • TR-287 (NIH Number: 86-2543)  (Peer Review Approval 07/27/1984A )
      Toxicology and Carcinogenesis Studies of Dimethyl Hydrogen Phosphite (CASRN 868-85-9) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: MR&M: 0, 100, 200, FR: 0, 50, 100 MG/KG/50 PER GROUP.
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Equivocal Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 

Special Studies

  • Absorption Distribution Metabolism Excretion (Intravenous; Gavage)  (S0081)  Completed 
    • Citation: Nomeir AA, Uraih LC. Pathological and biochemical effects of dimethyl hydrogen phosphite in Fischer 344 rats. Fundam Appl Toxicol. 1988 Jan;10(1):114-24.Pubmed Abstract
    • Male Rats [R]: F344/N; Male Rats [R]
    • Dose: (intravenous) 1000 mg/kg [R]. (gavage) 200, 1000 mg/kg [R].
  • Mechanisms (in-vitro)  (S0502)  Completed 
    • Citation: Nomeir AA, Burka LT, Matthews HB. Analysis of dimethyl hydrogen phosphite and its stability under simulated physiological conditions. J Anal Toxicol. 1988 Nov-Dec;12(6):334-8.Pubmed Abstract
    • []

Genetic Toxicology

  • Chromosome Aberrations  (515672)  Completed 
    • Mice
    •  Positive (Nonstandard Protocol) 
  • Drosophila  (292004)  Completed 
    • Citation: Woodruff RC, Mason JM, Valencia R, Zimmering S. Chemical mutagenesis testing in Drosophila. V. Results of 53 coded compounds tested for the National Toxicology Program. Environ Mutagen. 1985;7(5):677-702. doi: 10.1002/em.2860070507
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • In Vitro Cytogenetics (CA/SCE)  (601658)  Completed 
    • Citation: Gulati DK, Witt K, Anderson B, Zeiger E, Shelby MD. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro. III. Results with 27 chemicals. Environ Mol Mutagen. 1989;13(2):133-93. doi: 10.1002/em.2850130208
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Micronucleus  (224367)  Completed 
    • Citation: Shelby MD, Erexson GL, Hook GJ, Tice RR. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: results with 49 chemicals. Environ Mol Mutagen. 1993;21(2):160-79
    • Mice: B6C3F1
    • Male Positive 
  • Mouse Lymphoma  (199344)  Completed 
    • Citation: McGregor DB, Brown A, Cattanach P, Edwards I, McBride D, Caspary WJ. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay. II: 18 coded chemicals. Environ Mol Mutagen. 1988;11(1):91-118. doi: 10.1002/em.2850110110
    • Mice
    •  Positive 
  • Salmonella  (772334)  Completed 
    • Citation: Mortelmans K, Haworth S, Lawlor T, Speck W, Tainer B, Zeiger E. Salmonella mutagenicity tests: II. Results from the testing of 270 chemicals. Environ Mutagen. 1986;8 Suppl 7:1-119
    •  Equivocal 
  • Salmonella  (940869)  Completed 
    • Citation: Mortelmans K, Haworth S, Lawlor T, Speck W, Tainer B, Zeiger E. Salmonella mutagenicity tests: II. Results from the testing of 270 chemicals. Environ Mutagen. 1986;8 Suppl 7:1-119
    •  Weakly Positive 
  • Sister Chromatid Exchanges  (515672)  Completed 
    • Mice
    • Sister Chromatid  Positive (Nonstandard Protocol)