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Testing Status of Proflavin hydrochloride 10666-L

 

CASRN: 952-23-8

Formula: C13-H11-N3.Cl-H

Synonyms/Common Names

  • 3,6-Acridinediamine monohydrochloride (9CI)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C04137)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C04137)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 500, 2000 (AVG), M: 0, 200, 1400 (AVG) PPM/5 PER GROUP.

Long-Term Carcinogenicity

  • 109 weeks (Dosed-Feed)  (C04137)  Completed 
    • TR-005 (NIH Number: 77-805)  (Peer Review Approval 03/25/1977A )
      Bioassay of Proflavine for Possible Carcinogenicity (CASRN 952-23-8)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Equivocal 
      • Female Rats Negative 
      • Male Mice Equivocal 
      • Female Mice Equivocal 
    • Dose: R: 0, 300, 600, M: 0, 200, 400 PPM/50 PER GROUP.

Genetic Toxicology

  • Salmonella  (N-9202)  Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248