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Testing Status of Acetohexamide 10667-R

 

CASRN: 968-81-0

Formula: C15-H20-N2-O4-S

Synonyms/Common Names

  • 4-Acetyl-N-((cyclohexylamino)carbonyl)benzenesulfonamide
  • Dymelor

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C03247)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C03247)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: MR: 0, 1200, 30000, FM: 0, 2500, 40000 PPM/10 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C03247)  Completed 
    • TR-050 (NIH Number: 78-850)  (Peer Review Approval 03/06/1978A )
      Bioassay of Acetohexamide for Possible Carcinogenicity (CASRN 968-81-0)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: R: 0, 10000, 20000, M: 0, 7500, 15000 (AVG) PPM/35 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (722971)  Completed 
    • Sister Chromatid Exchange Not a Valid Test 
    • Chromosome Aberrations Negative 
  • Mouse Lymphoma  (677347)  Completed 
    • Mice
    •  Negative 
  • Salmonella  (576628)  Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Negative 
  • Salmonella  (N-9348)  Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248