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Testing Status of N-(1-Naphthyl)ethylenediamine dihydrochloride 10683-R


CASRN: 1465-25-4

Formula: C12-H14-N2.2Cl-H

Synonyms/Common Names

  • N-1-Naphthalenyl-1,2-ethanediamine dihydrochloride (9CI)
  • N-(1-Naphthyl)ethylenediamine

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C03281)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C03281)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, .03, 3.0, M: 0, .003, .3 %/5 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C03281)  Completed 
    • TR-168 (NIH Number: 79-1724)  (Peer Review Approval 08/31/1978A )
      Bioassay of N-(1-Naphthyl)ethylenediamine Dihydrochloride for Possible Carcinogenicity (CASRN 1465-25-4)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: R&MM: 0, .05, .1, FM: 0, .2, .3 (AVG) %/50 PER GROUP.

Genetic Toxicology

  • Drosophila  (696962)  Completed 
    • Citation: Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • In Vitro Cytogenetics (CA/SCE)  (494331)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Mouse Lymphoma  (356358)  Completed 
    • Mice
    •  Negative 
  • Salmonella  (579654)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Positive