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Testing Status of Chlorothalonil 10692-V

CASRN: 1897-45-6

Formula: C8-Cl4-N2

Synonyms/Common Names

  • 2,4,5,6-Tetrachloro-1,3-benzenedicarbonitrile (8CI)(9CI)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C00102)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C00102)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Dose: R: 0, 1250, 20000, M: 0, 1250, 40000 PPM/5 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C00102)  Completed 
    • TR-041 (NIH Number: 78-841)  (Peer Review Approval 06/29/1978A )
      Bioassay of Chlorothalonil for Possible Carcinogenicity (CASRN 1897-45-6)
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Dose: R: 0, 5063, 10126 (AVG), FM: 0, 3000, 6000 (AVG), MM: 0, 2688, 5375 (AVG) PPM/50 PER GROUP.
    • Carcinogenesis Results
      • Male Rats Positive 
      • Female Rats Positive 
      • Male Mice Negative 
      • Female Mice Negative 

Genetic Toxicology

  • Drosophila  (315727)  Completed 
    • Citation: Yoon JS, Mason JM, Valencia R, Woodruff RC, Zimmering S. Chemical mutagenesis testing in Drosophila. IV. Results of 45 coded compounds tested for the National Toxicology Program. Environ Mutagen. 1985;7(3):349-67. doi: 10.1002/em.2860070310
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • In Vitro Cytogenetics (CA/SCE)  (739007)  Completed 
    • Citation: Galloway SM, Armstrong MJ, Reuben C, Colman S, Brown B, Cannon C, Bloom AD, Nakamura F, Ahmed M, Duk S, Rimpo J, Margolin B, Resnick M, Anderson B, and Zeiger E. Chromosome aberrations and sister chromatid exchanges in Chinese hamster ovary cells: evaluations of 108 chemicals. Environ Mol Mutagen. 1987;10 Suppl 10:1-175. doi: 10.1002/em.2850100502
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Mouse Lymphoma  (351015)  Completed 
    • Citation: McGregor DB, Brown A, Cattanach P, Edwards I, McBride D, Riach C, Caspary WJ. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ Mol Mutagen. 1988;12(1):85-154. doi: 10.1002/em.2860120111. Erratum in: Environ Mol Mutagen 1988;12(3):345
    • Mice
    •  Positive 
  • Salmonella  (323726)  Completed 
    • Citation: Mortelmans K, Haworth S, Lawlor T, Speck W, Tainer B, Zeiger E. Salmonella mutagenicity tests: II. Results from the testing of 270 chemicals. Environ Mutagen. 1986;8 Suppl 7:1-119
    •  Negative