Testing Status of Chlorothalonil 10692-V
CASRN: 1897-45-6
Formula: C8-Cl4-N2
Synonyms/Common Names
- 2,4,5,6-Tetrachloro-1,3-benzenedicarbonitrile (8CI)(9CI)
Short-Term Toxicity
- 14-Day (Dosed-Feed)
(C00102)
Completed
- Rats: Osborne Mendel; Mice: B6C3F1
- 13-Week (Dosed-Feed)
(C00102)
Completed
- Rats: Osborne Mendel; Mice: B6C3F1
- Dose: R: 0, 1250, 20000, M: 0, 1250, 40000 PPM/5 PER GROUP.
Long-Term Carcinogenicity
- 2-Year (Dosed-Feed)
(C00102)
Completed
- TR-041 (NIH Number: 78-841)
(Peer Review Approval 06/29/1978A )
Bioassay of Chlorothalonil for Possible Carcinogenicity (CASRN 1897-45-6) - Rats: Osborne Mendel; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Positive
- Female Rats Positive
- Male Mice Negative
- Female Mice Negative
- Dose: R: 0, 5063, 10126 (AVG), FM: 0, 3000, 6000 (AVG), MM: 0, 2688, 5375 (AVG) PPM/50 PER GROUP.
- TR-041 (NIH Number: 78-841)
(Peer Review Approval 06/29/1978A )
Genetic Toxicology
- Drosophila
(315727)
Completed
- Citation: Yoon, J.S., Mason, J.M., Valencia, R., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: IV. Results of 45 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 349-367
- Reciprocal Translocation/Sex-Linked Recessive Lethal Negative
- In Vitro Cytogenetics (CA/SCE)
(739007)
Completed
- Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
- Sister Chromatid Exchange Positive
- Chromosome Aberrations Positive
- Mouse Lymphoma
(351015)
Completed
- Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
- Mice
- Positive
- Salmonella
(323726)
Completed
- Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
- Negative