Testing Status of 1,2,4,5-Tetrachlorobenzene 10696-K
CASRN: 95-94-3
Formula: C6-H2-Cl4
Synonyms/Common Names
- Benzene tetrachloride
Short-Term Toxicity
- 2 weeks (Dosed-Feed)
(C61949)
Completed
- TOX-07 (NIH Number: 91-3126)
(Peer Review Approval 11/21/1989A )
Toxicity Studies of 1,2,4,5-Tetrachlorobenzene in F344/N Rats and B6C3F1 Mice (Feed Studies) (CASRN 95-94-3) - Rats: F344/N; Mice: B6C3F1
- TOX-07 (NIH Number: 91-3126)
(Peer Review Approval 11/21/1989A )
- 13 weeks (Dosed-Feed)
(C61949)
Completed
- TOX-07 (NIH Number: 91-3126)
Toxicity Studies of 1,2,4,5-Tetrachlorobenzene in F344/N Rats and B6C3F1 Mice (Feed Studies) (CASRN 95-94-3) - Rats: F344/N; Mice: B6C3F1
- Dose: R&M: 0, 30, 100, 300, 1000, 2000 PPM.
- TOX-07 (NIH Number: 91-3126)
Special Studies
- Absorption Distribution Metabolism Excretion (Gavage)
(S0065)
Completed
- Male Rats [R]: F344/N
Genetic Toxicology
- Chromosome Aberrations
(411920)
Completed
- Mice
- Negative
- In Vitro Cytogenetics (CA/SCE)
(275349)
Completed
- Citation: Loveday KS, Anderson BE, Resnick MA, Zeiger E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro. V: Results with 46 chemicals. Environ Mol Mutagen. 1990;16(4):272-303. doi: 10.1002/em.2850160409
- Sister Chromatid Exchange Negative
- Chromosome Aberrations Negative
- Micronucleus
(A75526)
Completed
- Citation: Witt KL, Knapton A, Wehr CM, Hook GJ, Mirsalis J, Shelby MD, MacGregor JT. Micronucleated erythrocyte frequency in peripheral blood of B6C3F(1) mice from short-term, prechronic, and chronic studies of the NTP carcinogenesis bioassay program. Environ Mol Mutagen. 2000;36(3):163-94
- Mice: B6C3F1
- Male Negative
- Female Negative
- Salmonella
(235798)
Completed
- Citation: Haworth S, Lawlor T, Mortelmans K, Speck W, Zeiger E. Salmonella mutagenicity test results for 250 chemicals. Environ Mutagen. 1983;5 Suppl 1:1-142
- Negative
- Sister Chromatid Exchanges
(411920)
Completed
- Mice
- Sister Chromatid Negative
Organ Systems Toxicity
- greater than 120 days Continuous Breeding (Legacy) (Dosed-Feed)
(RACB89010)
Completed
- Male and Female Mice: Swiss
- Dose: 0, .05, .1, .2, .4, .6%; 0, .028, .072, .18%; N/A; 0, .072%.