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Testing Status of 1,2,4,5-Tetrachlorobenzene 10696-K

CASRN: 95-94-3

Formula: C6-H2-Cl4

Synonyms/Common Names

  • Benzene tetrachloride

Short-Term Toxicity

  • 2 weeks (Dosed-Feed)  (C61949)  Completed 
    • TOX-07 (NIH Number: 91-3126)  (Peer Review Approval 11/21/1989A )
      Toxicity Studies of 1,2,4,5-Tetrachlorobenzene in F344/N Rats and B6C3F1 Mice (Feed Studies) (CASRN 95-94-3)
    • Rats: F344/N; Mice: B6C3F1
  • 13 weeks (Dosed-Feed)  (C61949)  Completed 
    • TOX-07 (NIH Number: 91-3126)
      Toxicity Studies of 1,2,4,5-Tetrachlorobenzene in F344/N Rats and B6C3F1 Mice (Feed Studies) (CASRN 95-94-3)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 30, 100, 300, 1000, 2000 PPM.

Special Studies

  • Absorption Distribution Metabolism Excretion (Gavage)  (S0065)  Completed 
    • Male Rats [R]: F344/N

Genetic Toxicology

  • Chromosome Aberrations  (411920)  Completed 
    • Mice
    •  Negative 
  • In Vitro Cytogenetics (CA/SCE)  (275349)  Completed 
    • Citation: Loveday KS, Anderson BE, Resnick MA, Zeiger E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro. V: Results with 46 chemicals. Environ Mol Mutagen. 1990;16(4):272-303. doi: 10.1002/em.2850160409
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Micronucleus  (A75526)  Completed 
    • Citation: Witt KL, Knapton A, Wehr CM, Hook GJ, Mirsalis J, Shelby MD, MacGregor JT. Micronucleated erythrocyte frequency in peripheral blood of B6C3F(1) mice from short-term, prechronic, and chronic studies of the NTP carcinogenesis bioassay program. Environ Mol Mutagen. 2000;36(3):163-94
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (235798)  Completed 
    • Citation: Haworth S, Lawlor T, Mortelmans K, Speck W, Zeiger E. Salmonella mutagenicity test results for 250 chemicals. Environ Mutagen. 1983;5 Suppl 1:1-142
    •  Negative 
  • Sister Chromatid Exchanges  (411920)  Completed 
    • Mice
    • Sister Chromatid  Negative 

Organ Systems Toxicity

  • greater than 120 days Continuous Breeding (Legacy) (Dosed-Feed)  (RACB89010)  Completed 
    • Male and Female Mice: Swiss
    • Dose: 0, .05, .1, .2, .4, .6%; 0, .028, .072, .18%; N/A; 0, .072%.