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Testing Status of Mirex 10699-X

CASRN: 2385-85-5

Formula: C10-Cl12

Synonyms/Common Names

  • 1,1a,2,2,3,3a,4,5,5,5a,5b,6-Dodecachlorooctahydro-1,3,4-metheno-1H-cyclobuta(cd)pentalene (9CI)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C06428A)  Completed 
    • Rats: F344/N
  • 26 weeks (Dosed-Feed)  (C06428A)  Completed 
    • Rats: F344/N

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C06428A)  Completed 
    • TR-313 (NIH Number: 90-2569)  (Peer Review Approval 03/04/1987A )
      Toxicology and Carcinogenesis Studies of Mirex (1,1a,2,2,3,3a,4,5,5,5a,5b,6-Dodecachlorooctahydro-1,3,4-metheno-1H-cyclobuta[cd]pentalene) (CASRN 2385-85-5) in F344/N Rats (Feed Studies)
    • Rats: F344/N
    • Dose: MR&FR:0, 0.1, 1, 10, 25, 50 (2ND STUDY) FR:0, 50, 100 PPM/52 PER GROUP.
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Clear Evidence 

Special Studies

  • Cell Proliferation (Dosed-Feed)  (S0164)  Completed 
    • Citation: Yarbrough J, Cunningham M, Yamanaka H, Thurman R, Badr M. Carbohydrate and oxygen metabolism during hepatocellular proliferation: a study in perfused livers from mirex-treated rats. Hepatology. 1991 Jun;13(6):1229-34.Pubmed Abstract
    • Male Rats [R]: Sprague Dawley
    • Dose: (dosed-feed) 100 MG/KG [R].

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (473171)  Completed 
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Salmonella  (109625)  Completed 
    • Citation: Mortelmans K, Haworth S, Lawlor T, Speck W, Tainer B, Zeiger E. Salmonella mutagenicity tests: II. Results from the testing of 270 chemicals. Environ Mutagen. 1986;8 Suppl 7:1-119
    •  Negative