Testing Status of Mirex 10699-X

CASRN: 2385-85-5

Formula: C10-Cl12

Synonyms/Common Names

• 1,1a,2,2,3,3a,4,5,5,5a,5b,6-Dodecachlorooctahydro-1,3,4-metheno-1H-cyclobuta(cd)pentalene (9CI)

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C06428A)  Completed 
  • Rats: F344/N
• 26 weeks (Dosed-Feed)  (C06428A)  Completed 
  • Rats: F344/N

Long-Term Carcinogenicity

• 2 years (Dosed-Feed)  (C06428A)  Completed 
  • TR-313 (NIH Number: 90-2569)  (Peer Review Approval 03/04/1987A )
    Toxicology and Carcinogenesis Studies of Mirex (1,1a,2,2,3,3a,4,5,5,5a,5b,6-Dodecachlorooctahydro-1,3,4-metheno-1H-cyclobuta[cd]pentalene) (CASRN 2385-85-5) in F344/N Rats (Feed Studies)
  • Rats: F344/N
  • Dose: MR&FR:0, 0.1, 1, 10, 25, 50 (2ND STUDY) FR:0, 50, 100 PPM/52 PER GROUP.
  • Carcinogenesis Results
    • Male Rats Clear Evidence 
    • Female Rats Clear Evidence 

Special Studies

• Cell Proliferation (Dosed-Feed)  (S0164)  Completed 
  • Citation: Yarbrough J, Cunningham M, Yamanaka H, Thurman R, Badr M. Carbohydrate and oxygen metabolism during hepatocellular proliferation: a study in perfused livers from mirex-treated rats. Hepatology. 1991 Jun;13(6):1229-34.Pubmed Abstract
  • Male Rats [R]: Sprague Dawley
  • Dose: (dosed-feed) 100 MG/KG [R].

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (473171)  Completed 
  • Sister Chromatid Exchange Negative 
  • Chromosome Aberrations Negative 
• Salmonella  (109625)  Completed 
  • Citation: Mortelmans K, Haworth S, Lawlor T, Speck W, Tainer B, Zeiger E. Salmonella mutagenicity tests: II. Results from the testing of 270 chemicals. Environ Mutagen. 1986;8 Suppl 7:1-119
  •  Negative