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Testing Status of 2,3,5,6-Tetrachloro-4-nitroanisole 10705-R

CASRN: 2438-88-2

Formula: C7-H3-Cl4-N-O3

Synonyms/Common Names

  • 1,2,4,5-Tetrachloro-3-methoxy-6-nitro- (9CI)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C03032)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C03032)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, .003, .4 %/10 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C03032)  Completed 
    • TR-114 (NIH Number: 78-1369)  (Peer Review Approval 06/29/1978A )
      Bioassay of 2,3,5,6-Tetrachloro-4-nitroanisole for Possible Carcinogenicity (CASRN 2438-88-2)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, .006, .012 %/50 PER GROUP.
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (997382)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Equivocal 
  • Mouse Lymphoma  (665415)  Completed 
    • Citation: McGregor DB, Brown A, Cattanach P, Edwards I, McBride D, Riach C, Caspary WJ. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ Mol Mutagen. 1988;12(1):85-154. doi: 10.1002/em.2860120111. Erratum in: Environ Mol Mutagen 1988;12(3):345
    • Mice
    •  Positive 
  • Salmonella  (966907)  Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K. Salmonella mutagenicity tests: V. Results from the testing of 311 chemicals. Environ Mol Mutagen. 1992;19 Suppl 21:2-141. doi: 10.1002/em.2850190603
    •  Negative