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Testing Status of C.I. Disperse Blue 1 10707-Y

CASRN: 2475-45-8

Formula: C14-H12-N4-O2

Synonyms/Common Names

  • 1,4,5,8-Tetraamino-9,10-anthracenedione
  • 1,4,5,8-Tetraaminoanthraquinone

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C54900)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C54900)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 1200, 20000, M: 0, 600, 10000 PPM/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C54900)  Completed 
    • TR-299 (NIH Number: 86-2555)  (Peer Review Approval 03/29/1985A )
      Toxicology and Carcinogenesis Studies of C.I. Disperse Blue 1 (A commercial dye containing approximately 50% 1,4,5,8-tetraaminoanthraquinone, and 20% water) (CASRN 2475-45-8) in F344/N Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 12500, 2500, 5000, M: 0, 600, 1200, 2500 PPM/50 PER GROUP.
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Clear Evidence 
      • Male Mice Equivocal Evidence 
      • Female Mice No Evidence 

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (776658)  Completed 
    • Citation: Anderson BE, Zeiger E, Shelby MD, Resnick MA, Gulati DK, Ivett JL, Loveday KS. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ Mol Mutagen. 1990;16 Suppl 18:55-137. doi: 10.1002/em.2850160505
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Micronucleus  (A40953)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Mouse Lymphoma  (334618)  Completed 
    • Citation: Myhr B, McGregor D, Bowers L, Riach C, Brown AG, Edwards I, McBride D, Martin R, Caspary WJ. L5178Y mouse lymphoma cell mutation assay results with 41 compounds. Environ Mol Mutagen. 1990;16 Suppl 18:138-67. doi: 10.1002/em.2850160506
    • Mice
    •  Positive 
  • Salmonella  (336679)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K. Salmonella mutagenicity tests: IV. Results from the testing of 300 chemicals. Environ Mol Mutagen. 1988;11 Suppl 12:1-157
    •  Positive