Testing Status of 2,2-bis(Bromomethyl)-1,3-propanediol 10722-V
CASRN: 3296-90-0
Related: FISH PROJECT 1 (2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL
Formula: C5-H10-Br2-O2
Synonyms/Common Names
- Pentaerythritol dibromide
Short-Term Toxicity
- 14-Day (Gavage)
(C55516A)
Completed
- Rats: F344/N; Mice: B6C3F1
- 13-Week (Gavage)
(C55516A)
Completed
- Rats: F344/N; Mice: B6C3F1
- Dose: R: 0, 50, OR 800, M: 0, 25, OR 400 MG/KG; 10 PER GROUP.
- 13-Week (Dosed-Feed)
(C55516B)
Completed
- Rats: F344/N; Mice: B6C3F1
- Dose: R: 0, 1250, 20000, M: 0, 625, 10000 PPM/5 PER GROUP.
Long-Term Carcinogenicity
- 2 years (Dosed-Feed)
(C55516C)
Completed
- TR-452 (NIH Number: 96-3368)
(Peer Review Approval 11/29/1994A )
Toxicology and Carcinogenesis Studies of 2,2-Bis(Bromomethyl)-1,3-Propanediol (FR-1138) in F344/N Rats and B6C3F1 Mice (Feed Studies) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Clear Evidence
- Female Rats Clear Evidence
- Male Mice Clear Evidence
- Female Mice Clear Evidence
- Dose: R: 0, 2500, 5000, OR 10000 PPM; STOP STUDY: MALES 20000 PPM; 70/GROUP M: 0, 312, 625, OR 1250 PPM; 60/GROUP.
- TR-452 (NIH Number: 96-3368)
(Peer Review Approval 11/29/1994A )
Special Studies
- Absorption Distribution Metabolism Excretion (Gavage; Intravenous; in-vitro; Gavage; in-vitro)
(S0977)
Completed
- Male Rats: F344/N; Female Mice: B6C3F1
- Dose: 10 mg/kg. 10, 100 mg/kg. 100 mg/kg. 100 uM.
- Toxicokinetic Study (Gavage; Intravenous; Gavage; Intravenous)
(S0554)
Completed
- Citation: Hoehle SI, Knudsen GA, Sanders JM, Sipes IG. Absorption, distribution, metabolism, and excretion of 2,2-bis(bromomethyl)-1,3-propanediol in male fischer-344 rats. Drug Metab Dispos. 2009 Feb;37(2):408-16. doi: 10.1124/dmd.108.023937. Epub 2008 Nov 24.Pubmed Abstract
- Male Rats: F344/N; Male Mice: B6C3F1
- Dose: 15 mg/kg [R,M]. 150, 300, 600 mg/kg [R,M].
Genetic Toxicology
- In Vitro Cytogenetics (CA/SCE)
(487287)
Completed
- Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
- Sister Chromatid Exchange Equivocal
- Chromosome Aberrations Positive
- Micronucleus
(303529)
Completed
- Mice: B6C3F1
- Male Equivocal
- Salmonella
(380647)
Completed
- Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
- Positive
- Salmonella
(933355)
Completed
- Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
- Negative
- Salmonella
(A70660)
Completed
- Positive
Organ Systems Toxicity
- 120 day minimum Continuous Breeding (Legacy) (Dosed-Feed)
(RACB85043)
Completed
- Male and Female Mice: Swiss
- Dose: N/A; 0, 0.025, .05, .1, .25, .5%; N/A; N/A.