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Testing Status of 2,2-bis(Bromomethyl)-1,3-propanediol 10722-V

CASRN: 3296-90-0

Formula: C5-H10-Br2-O2

Synonyms/Common Names

  • Pentaerythritol dibromide

Short-Term Toxicity

  • 14-Day (Gavage)  (C55516A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C55516A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 50, OR 800, M: 0, 25, OR 400 MG/KG; 10 PER GROUP.
  • 13-Week (Dosed-Feed)  (C55516B)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 1250, 20000, M: 0, 625, 10000 PPM/5 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C55516C)  Completed 
    • TR-452 (NIH Number: 96-3368)  (Peer Review Approval 11/29/1994A )
      Toxicology and Carcinogenesis Studies of 2,2-Bis(Bromomethyl)-1,3-Propanediol (FR-1138) (CASRN 3296-90-0) in F344/N Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 2500, 5000, OR 10000 PPM; STOP STUDY: MALES 20000 PPM; 70/GROUP M: 0, 312, 625, OR 1250 PPM; 60/GROUP.
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Clear Evidence 
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 

Special Studies

  • Absorption Distribution Metabolism Excretion (Gavage; Intravenous; in-vitro; Gavage; in-vitro)  (S0977)  Completed 
    • Male Rats [R]: F344/N; Female Mice [M]: B6C3F1
    • Dose: (gavage) 10, 100 mg/kg [R]. (intravenous) 10 mg/kg [R]. (in-vitro) 100 uM [R,M]. (gavage) 100 mg/kg [M].
  • Toxicokinetic Study (Gavage; Intravenous; Gavage; Intravenous)  (S0554)  Completed 
    • Citation: Hoehle SI, Knudsen GA, Sanders JM, Sipes IG. Absorption, distribution, metabolism, and excretion of 2,2-bis(bromomethyl)-1,3-propanediol in male fischer-344 rats. Drug Metab Dispos. 2009 Feb;37(2):408-16. doi: 10.1124/dmd.108.023937. Epub 2008 Nov 24.Pubmed Abstract
    • Male Rats [R]: F344/N; Male Mice [M]: B6C3F1
    • Dose: (gavage) 150, 300, 600 mg/kg [R,M]. (intravenous) 15 mg/kg [R,M].

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (487287)  Completed 
    • Citation: Galloway SM, Armstrong MJ, Reuben C, Colman S, Brown B, Cannon C, Bloom AD, Nakamura F, Ahmed M, Duk S, Rimpo J, Margolin B, Resnick M, Anderson B, and Zeiger E. Chromosome aberrations and sister chromatid exchanges in Chinese hamster ovary cells: evaluations of 108 chemicals. Environ Mol Mutagen. 1987;10 Suppl 10:1-175. doi: 10.1002/em.2850100502
    • Sister Chromatid Exchange Equivocal 
    • Chromosome Aberrations Positive 
  • Micronucleus  (303529)  Completed 
    • Mice: B6C3F1
    • Male Equivocal 
  • Salmonella  (380647)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K. Salmonella mutagenicity tests: V. Results from the testing of 311 chemicals. Environ Mol Mutagen. 1992;19 Suppl 21:2-141. doi: 10.1002/em.2850190603
    •  Positive 
  • Salmonella  (933355)  Completed 
    • Citation: Mortelmans K, Haworth S, Lawlor T, Speck W, Tainer B, Zeiger E. Salmonella mutagenicity tests: II. Results from the testing of 270 chemicals. Environ Mutagen. 1986;8 Suppl 7:1-119
    •  Negative 
  • Salmonella  (A70660)  Completed 
    •  Positive 

Organ Systems Toxicity

  • 120 day minimum Continuous Breeding (Legacy) (Dosed-Feed)  (RACB85043)  Completed 
    • Male and Female Mice: Swiss
    • Dose: N/A; 0, 0.025, .05, .1, .25, .5%; N/A; N/A.