Testing Status of 2,5-Toluenediamine sulfate 10736-T
CASRN: 6369-59-1
Formula: C7-H10-N2.x-H2-O4-S
Synonyms/Common Names
- 2-Methyl-1,4-benzenediamine sulfate (9CI)
Short-Term Toxicity
- 14-Day (Dosed-Feed)
(C01832)
Completed
- Rats: F344/N; Mice: B6C3F1
- 13-Week (Dosed-Feed)
(C01832)
Completed
- Rats: F344/N; Mice: B6C3F1
- Dose: 0, .02, .11 %/10 PER GROUP.
Long-Term Carcinogenicity
- 2-Year (Dosed-Feed)
(C01832)
Completed
- TR-126 (NIH Number: 78-1381)
(Peer Review Approval 06/25/1978A )
Bioassay of 2,5-Toluenediamine Sulfate for Possible Carcinogenicity (CASRN 6369-59-1) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Negative
- Female Rats Negative
- Male Mice Negative
- Female Mice Negative
- Dose: R: 0, .06, .2 (AVG), M: 0, .06, .1 (AVG) %/50 PER GROUP.
- TR-126 (NIH Number: 78-1381)
(Peer Review Approval 06/25/1978A )
Genetic Toxicology
- In Vitro Cytogenetics (CA/SCE)
(951026)
Completed
- Sister Chromatid Exchange Positive
- Chromosome Aberrations Positive
- Mouse Lymphoma
(821795)
Completed
- Mice
- Positive
- Salmonella
(578137)
Completed
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
- Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
- Positive
- Salmonella
(N-9356)
Completed
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248
Organ Systems Toxicity
- 6 to 15 GD Conventional Teratology (Subcutaneous Injection)
(T0133)
Completed
- Female Mice: Swiss
- Dose: 0, 16, 32, 48, 64 MG/KG/DAY.