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Testing Status of DL-menthol 10767-W

 

CASRN: 15356-70-4

Formula: C10-H20-O

Synonyms/Common Names

  • Cyclohexanol, 5-methyl-2-(1-methylethyl)-(1alpha,2beta,5alpha)- (9CI)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C50000)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C50000)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 930, 15000 PPM/10 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C50000)  Completed 
    • TR-098 (NIH Number: 79-1348)  (Peer Review Approval 08/31/1978A )
      Bioassay of dl-Menthol for Possible Carcinogenicity (CASRN 89-78-1)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: R: 0, 3750, 7500, M: 0, 2000, 4000 PPM/50 PER GROUP.

Genetic Toxicology

  • Chromosome Aberrations  (097978)  Completed 
    • Mice
    •  Equivocal 
  • Drosophila  (231138)  Completed 
    • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • In Vitro Cytogenetics (CA/SCE)  (423321)  Completed 
    • Citation: Ivett, J.L., Brown, B.M., Rodgers, C., Anderson, B.E., Resnick, M.A., Zeiger, E. Chromosomal aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro IV: Results for 15 chemicals Environ. Molec. Mutagen. Vol. 14 (1989) 165-187
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Micronucleus  (813096)  Completed 
    • Citation: Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179
    • Mice: B6C3F1
    • Male Negative 
  • Mouse Lymphoma  (979487)  Completed 
    • Citation: Myhr, B. and Caspary, W. Chemical mutagenesis at the TK locus in L5178Y mouse lymphoma cells. I. Results for 31 coded compounds in the National Toxicology Program. Environ. Molec. Mutagen. Vol. 18 (1991) 51-83
    • Mice
    •  Negative 
  • Salmonella  (506811)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
    •  Negative 
  • Sister Chromatid Exchanges  (097978)  Completed 
    • Mice
    • Sister Chromatid  Negative (Nonstandard Protocol)