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Testing Status of Cytembena 10778-H

CASRN: 21739-91-3

Formula: C11-H9-Br-O4.Na

Synonyms/Common Names

  • 2-Butenoic acid, 3-bromo-4-(4-methoxyphenyl)-4-oxo-, sodium salt, (E)- (9CI)

Short-Term Toxicity

  • 13-Week (Intraperitoneal Injection)  (C50737)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 1.8, 29, M: 0, 3.0, 48 MG/KG/10 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Intraperitoneal Injection)  (C50737)  Completed 
    • TR-207 (NIH Number: 81-1763)  (Peer Review Approval 06/27/1980A )
      Carcinogenesis Bioassay of Cytembena (CASRN 21739-91-3)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 7, 14, M: 0, 12, 24 MG/KG/50 PER GROUP.
    • Carcinogenesis Results
      • Male Rats Positive 
      • Female Rats Positive 
      • Male Mice Negative 
      • Female Mice Negative 

Genetic Toxicology

  • Chromosome Aberrations  (483291)  Completed 
    • Mice
    •  Negative 
  • Drosophila  (861418)  Completed 
    • Citation: Foureman P, Mason JM, Valencia R, Zimmering S. Chemical mutagenesis testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ Mol Mutagen. 1994;23(1):51-63. doi: 10.1002/em.2850230109
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • In Vitro Cytogenetics (CA/SCE)  (404197)  Completed 
    • Citation: Ivett, J.L., Brown, B.M., Rodgers, C., Anderson, B.E., Resnick, M.A., Zeiger, E. Chromosomal aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro IV: Results for 15 chemicals Environ. Molec. Mutagen. Vol. 14 (1989) 165-187
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Micronucleus  (983684)  Completed 
    • Citation: Shelby MD, Erexson GL, Hook GJ, Tice RR. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: results with 49 chemicals. Environ Mol Mutagen. 1993;21(2):160-79
    • Mice: B6C3F1
    • Male Negative 
  • Mouse Lymphoma  (644192)  Completed 
    • Citation: McGregor DB, Brown AG, Howgate S, McBride D, Riach C, Caspary WJ. Responses of the L5178Y mouse Lymphoma cell forward mutation assay. V: 27 coded chemicals. Environ Mol Mutagen. 1991;17(3):196-219. doi: 10.1002/em.2850170309
    • Mice
    •  Positive 
  • Salmonella  (379904)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K. Salmonella mutagenicity tests: IV. Results from the testing of 300 chemicals. Environ Mol Mutagen. 1988;11 Suppl 12:1-157
    •  Positive 
  • Sister Chromatid Exchanges  (483291)  Completed 
    • Mice
    • Sister Chromatid  Negative (Nonstandard Protocol)