Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.


The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of Cytembena 10778-H

CASRN: 21739-91-3

Formula: C11-H9-Br-O4.Na

Synonyms/Common Names

  • 2-Butenoic acid, 3-bromo-4-(4-methoxyphenyl)-4-oxo-, sodium salt, (E)- (9CI)

Short-Term Toxicity

  • 13-Week (Intraperitoneal Injection)  (C50737)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 1.8, 29, M: 0, 3.0, 48 MG/KG/10 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Intraperitoneal Injection)  (C50737)  Completed 
    • TR-207 (NIH Number: 81-1763)  (Peer Review Approval 06/27/1980A )
      Carcinogenesis Bioassay of Cytembena (CASRN 21739-91-3)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 7, 14, M: 0, 12, 24 MG/KG/50 PER GROUP.
    • Carcinogenesis Results
      • Male Rats Positive 
      • Female Rats Positive 
      • Male Mice Negative 
      • Female Mice Negative 

Genetic Toxicology

  • Chromosome Aberrations  (483291)  Completed 
    • Mice
    •  Negative 
  • Drosophila  (861418)  Completed 
    • Citation: Foureman P, Mason JM, Valencia R, Zimmering S. Chemical mutagenesis testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ Mol Mutagen. 1994;23(1):51-63. doi: 10.1002/em.2850230109
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • In Vitro Cytogenetics (CA/SCE)  (404197)  Completed 
    • Citation: Ivett, J.L., Brown, B.M., Rodgers, C., Anderson, B.E., Resnick, M.A., Zeiger, E. Chromosomal aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro IV: Results for 15 chemicals Environ. Molec. Mutagen. Vol. 14 (1989) 165-187
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Micronucleus  (983684)  Completed 
    • Citation: Shelby MD, Erexson GL, Hook GJ, Tice RR. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: results with 49 chemicals. Environ Mol Mutagen. 1993;21(2):160-79
    • Mice: B6C3F1
    • Male Negative 
  • Mouse Lymphoma  (644192)  Completed 
    • Citation: McGregor DB, Brown AG, Howgate S, McBride D, Riach C, Caspary WJ. Responses of the L5178Y mouse Lymphoma cell forward mutation assay. V: 27 coded chemicals. Environ Mol Mutagen. 1991;17(3):196-219. doi: 10.1002/em.2850170309
    • Mice
    •  Positive 
  • Salmonella  (379904)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K. Salmonella mutagenicity tests: IV. Results from the testing of 300 chemicals. Environ Mol Mutagen. 1988;11 Suppl 12:1-157
    •  Positive 
  • Sister Chromatid Exchanges  (483291)  Completed 
    • Mice
    • Sister Chromatid  Negative (Nonstandard Protocol)