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Testing Status of 4-Acetylaminofluorene 10784-A

 

CASRN: 28322-02-3

Formula: C15-H13-N-O

Synonyms/Common Names

  • Acetamide, N-9H-fluoren-4-yl
  • Acetamide, N-9H-fluoren-4-yl- (9CI)

Genetic Toxicology

  • Chromosome Aberrations  (A19956)  Completed 
    • Mice
    •  Negative 
  • In Vitro Cytogenetics (CA/SCE)  (710698)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Mouse Lymphoma  (390698)  Completed 
    • Mice
    •  Positive 
  • Mouse Lymphoma  (888359)  Completed 
    • Citation: McGregor, D., Brown, A., Howgate, S., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay. IV: 27 coded chemicals. Environ. Molec. Mutagen. Vol. 17 (1991) 196-219
    • Mice
    •  Negative 
  • Mouse Lymphoma  (G12606)  Completed 
    • Citation: Myhr, B.C., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for sixty-three coded chemicals tested at Litton Bionetics, Inc. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 103-194
    • Mice
  • Mouse Lymphoma  (G42545)  Completed 
    • Citation: Mitchell, A.D., Rudd, C.J., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for 63 coded chemicals tested at SRI International. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 37-102
    • Mice
  • Salmonella  (N-9088)  Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1984) Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ. Mutagen. 6 (Suppl. 2): 1-251.
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol Environ. Mutagen. Vol. 6 (Suppl 2) (1984) 1-251
  • Sister Chromatid Exchanges  (A19956)  Completed 
    • Mice
    • Sister Chromatid  Equivocal 

Organ Systems Toxicity

  • Dominant Lethal (Female) (Dosed-Feed)  (DLF003)  Completed 
    • Citation: Generoso, W.M., Cain, K.T., Hughes, L.A., and Braden, P. W. Tests for induction of presumed dominant lethal effects in female mice, In: Evaluation of Short-Term Tests for Carcinogens: Report of the IPCS Collaborative Study on In Vivo Assays (J. Ashby, F.J. deSerres, M.D. Shelby, B.H. Margolin, M. Ishidate, and G.C. Becking, Eds.). Cambridge Univ. Press, Cambridge, UK, 1988, pp. 2.189-2.193.
    • Female Mice: C3H X 101
    • Mice Female Negative 
  • Dominant Lethal (Female)  (DLF004)  Completed 
    • Citation: Generoso, W.M., Cain, K.T., Hughes, L.A., and Braden, P. W. Tests for induction of presumed dominant lethal effects in female mice, In: Evaluation of Short-Term Tests for Carcinogens: Report of the IPCS Collaborative Study on In Vivo Assays (J. Ashby, F.J. deSerres, M.D. Shelby, B.H. Margolin, M. Ishidate, and G.C. Becking, Eds.). Cambridge Univ. Press, Cambridge, UK, 1988, pp. 2.189-2.193.
    • Female Mice: T-Stock
    • Mice Female Negative