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Testing Status of 4-Acetylaminofluorene 10784-A

CASRN: 28322-02-3

Formula: C15-H13-N-O

Synonyms/Common Names

  • Acetamide, N-9H-fluoren-4-yl
  • Acetamide, N-9H-fluoren-4-yl- (9CI)

Genetic Toxicology

  • Chromosome Aberrations  (A19956)  Completed 
    • Mice
    •  Negative 
  • In Vitro Cytogenetics (CA/SCE)  (710698)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Mouse Lymphoma  (390698)  Completed 
    • Mice
    •  Positive 
  • Mouse Lymphoma  (888359)  Completed 
    • Citation: McGregor DB, Brown AG, Howgate S, McBride D, Riach C, Caspary WJ. Responses of the L5178Y mouse Lymphoma cell forward mutation assay. V: 27 coded chemicals. Environ Mol Mutagen. 1991;17(3):196-219. doi: 10.1002/em.2850170309
    • Mice
    •  Negative 
  • Mouse Lymphoma  (G12606)  Completed 
    • Citation: Myhr BC, Caspary WJ. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: intralaboratory results for sixty-three coded chemicals tested at Litton Bionetics, Inc. Environ Mol Mutagen. 1988;12 Suppl 13:103-94. doi: 10.1002/em.2860120505
    • Mice
  • Mouse Lymphoma  (G42545)  Completed 
    • Citation: Mitchell AD, Rudd CJ, Caspary WJ. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: intralaboratory results for sixty-three coded chemicals tested at SRI International. Environ Mol Mutagen. 1988;12 Suppl 13:37-101. doi: 10.1002/em.2860120504
    • Mice
  • Salmonella  (N-9088)  Completed 
    • Citation: Dunkel VC, Zeiger E, Brusick D, McCoy E, McGregor D, Mortelmans K, Rosenkranz HS, Simmon VF. Reproducibility of microbial mutagenicity assays: I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ Mutagen. 1984;6 Suppl 2:1-251. doi: 10.1002/em.2860060702
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol Environ. Mutagen. Vol. 6 (Suppl 2) (1984) 1-251
  • Sister Chromatid Exchanges  (A19956)  Completed 
    • Mice
    • Sister Chromatid  Equivocal 

Organ Systems Toxicity

  • Dominant Lethal (Female) (Dosed-Feed)  (DLF003)  Completed 
    • Citation: Generoso, W.M., Cain, K.T., Hughes, L.A., and Braden, P. W. Tests for induction of presumed dominant lethal effects in female mice, In: Evaluation of Short-Term Tests for Carcinogens: Report of the IPCS Collaborative Study on In Vivo Assays (J. Ashby, F.J. deSerres, M.D. Shelby, B.H. Margolin, M. Ishidate, and G.C. Becking, Eds.). Cambridge Univ. Press, Cambridge, UK, 1988, pp. 2.189-2.193.
    • Female Mice: C3H X 101
    • Mice Female Negative 
  • Dominant Lethal (Female)  (DLF004)  Completed 
    • Citation: Generoso, W.M., Cain, K.T., Hughes, L.A., and Braden, P. W. Tests for induction of presumed dominant lethal effects in female mice, In: Evaluation of Short-Term Tests for Carcinogens: Report of the IPCS Collaborative Study on In Vivo Assays (J. Ashby, F.J. deSerres, M.D. Shelby, B.H. Margolin, M. Ishidate, and G.C. Becking, Eds.). Cambridge Univ. Press, Cambridge, UK, 1988, pp. 2.189-2.193.
    • Female Mice: T-Stock
    • Mice Female Negative