Testing Status of 1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin 10790-S

CASRN: 57653-85-7

Formula: C12-H2-Cl6-O2

Synonyms/Common Names

• 1,2,3,6,7,8-Hexachlorodibenzo(b,e)(1,4)dioxin (9CI)

Short-Term Toxicity

• 14-Day (Gavage)  (C03703A)  Completed 
  • Rats: Osborne Mendel; Mice: B6C3F1
• 14-Day (Topical Application)  (C03703B)  Completed 
  • Mice: Swiss Webster
• 13-Week (Gavage)  (C03703A)  Completed 
  • Rats: Osborne Mendel; Mice: B6C3F1
  • Dose: R: 0, 2.5, 100, M: 0, 1.25, 50 UG/KG/10 PER GROUP.
• 13-Week (Topical Application)  (C03703B)  Completed 
  • Mice: Swiss Webster
  • Dose: 0, .01, 50 UG/10 PER GROUP.

Long-Term Carcinogenicity

• 2-Year (Gavage)  (C03703A)  Completed 
  • TR-198 (NIH Number: 80-1754)  (Peer Review Approval 02/15/1980A )
    Bioassay of a Mixture of 1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin and 1,2,3,7,8,9-Hexachlorodibenzo-p-dioxin (Gavage) for Possible Carcinogenicity (CASRN 57653-85-7, CASRN 19408-74-3)
  • Rats: Osborne Mendel; Mice: B6C3F1
  • Dose: R&MM: 0, 1.25, 2.5, 5.0, FM: 0, 2.5, 5.0, 10.0 UG/KG/50 PER GROUP.
  • Carcinogenesis Results
    • Male Rats Equivocal 
    • Female Rats Positive 
    • Male Mice Positive 
    • Female Mice Positive 
• 2-Year (Topical Application)  (C03703B)  Completed 
  • TR-202 (NIH Number: 80-1758)  (Peer Review Approval 02/15/1980A )
    Bioassay of a Mixture of 1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin and 1,2,3,7,8,9-Hexachlorodibenzo-p-dioxin (Dermal Study) for Possible Carcinogenicity (CASRN 57653-85-7; CASRN 19408-74-3)
  • Mice: Swiss Webster
  • Dose: 0, .005, .01 UG/60 PER GROUP.
  • Carcinogenesis Results
    • Male Mice Negative 
    • Female Mice Negative 

Organ Systems Toxicity

• 14 days Immunotoxicity (Gavage)  (IMM84001)  Completed 
  • Female Mice: B6C3F1
  • Dose: 0, 0.056, 0.56 or 5.6 ug/kg HCDD and 0.86 ug/kg TCDD.