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Testing Status of Tetrakis(hydroxymethyl)phosphonium sulfate 10809-L


CASRN: 55566-30-8

Formula: C4-H12-O4-P.1/2O4-S

Synonyms/Common Names

  • Octakis(hydroxymethyl)phosphonium sulfate
  • THPS

Short-Term Toxicity

  • 2 weeks (Gavage)  (C55050)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 12.5, 25, 50, 100, 200 MG/KG.
  • 13 weeks (Gavage)  (C55050)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 5, 10, 20, 40, 60 MG/KG/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C55050)  Completed 
    • TR-296 (NIH Number: 87-2552)  (Peer Review Approval 03/26/1986A )
      Toxicology and Carcinogenesis Studies of Tetrakis(hydroxymethyl)phosphonium sulfate (THPS) (CASRN 55566-30-8) and Tetrakis(hydroxymethyl)phosphonium chloride (THPC) (CASRN 124-64-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: 0, 5, 10 MG/KG/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (322690)  Completed 
    • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Mouse Lymphoma  (981818)  Completed 
    • Citation: Myhr B.C., McGregor, D., Bowers, L., Riach, C., Brown, A., Edwards, I., McBride, D., Martin, R., and Caspary, W.J. L5178Y mouse lymphoma cell mutation assay results with 41 compounds. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 138-167
    • Mice
    •  Positive 
  • Salmonella  (337557)  Completed 
    • Citation: Zeiger, E. Mutagenicity of 42 chemicals in Salmonella Environ. Molec. Mutagen. Vol. 16(Suppl 18) (1990) 32-54
    •  Negative