Testing Status of Dichloromethotrexate 10836-Y

CASRN: 528-74-5

Formula: C20-H20-Cl2-N8-O5

Synonyms/Common Names

• N-(3,5-Dichloro-4-((2,4-diamino-6-pteridinylmethyl)methylamino)benzoyl)glutamic acid

Short-Term Toxicity

• 14-Day (Intraperitoneal Injection)  (C04875)  Completed 
  • Rats: Sprague Dawley; Mice: Swiss
• 13-Week (Intraperitoneal Injection)  (C04875)  Completed 
  • Rats: Sprague Dawley; Mice: Swiss

Long-Term Carcinogenicity

• 2-Year (Intraperitoneal Injection)  (C04875)  Completed 
  •   (Peer Review Approval NA) Citation: EK Weisburger, Bioassay Program for Carcinogenic Hazards of Cancer Chemotherapeutic Agents. Cancer 40:1935-1949 (1977)
  • Rats: Sprague Dawley; Mice: Swiss
  • Dose: R: 0, 3.75, 7.5, 15, 30, M: 0, 75, 150 MG/KG/25 PER GROUP.

Genetic Toxicology

• Salmonella  (197169)  Completed 
  • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
  •  Weakly Positive 
• Salmonella  (391111)  Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
  •  Negative 
• Salmonella  (467981)  Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
  •  Negative