Testing Status of Dichloromethotrexate 10836-Y
CASRN: 528-74-5
Formula: C20-H20-Cl2-N8-O5
Synonyms/Common Names
- N-(3,5-Dichloro-4-((2,4-diamino-6-pteridinylmethyl)methylamino)benzoyl)glutamic acid
Short-Term Toxicity
- 14-Day (Intraperitoneal Injection)
(C04875)
Completed
- Rats: Sprague Dawley; Mice: Swiss
- 13-Week (Intraperitoneal Injection)
(C04875)
Completed
- Rats: Sprague Dawley; Mice: Swiss
Long-Term Carcinogenicity
- 2-Year (Intraperitoneal Injection)
(C04875)
Completed
- (Peer Review Approval NA) Citation: EK Weisburger, Bioassay Program for Carcinogenic Hazards of Cancer Chemotherapeutic Agents. Cancer 40:1935-1949 (1977)
- Rats: Sprague Dawley; Mice: Swiss
- Dose: R: 0, 3.75, 7.5, 15, 30, M: 0, 75, 150 MG/KG/25 PER GROUP.
Genetic Toxicology
- Salmonella
(197169)
Completed
- Citation: Haworth S, Lawlor T, Mortelmans K, Speck W, Zeiger E. Salmonella mutagenicity test results for 250 chemicals. Environ Mutagen. 1983;5 Suppl 1:1-142
- Weakly Positive
- Salmonella
(391111)
Completed
- Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K. Salmonella mutagenicity tests: IV. Results from the testing of 300 chemicals. Environ Mol Mutagen. 1988;11 Suppl 12:1-157
- Negative
- Salmonella
(467981)
Completed
- Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K. Salmonella mutagenicity tests: IV. Results from the testing of 300 chemicals. Environ Mol Mutagen. 1988;11 Suppl 12:1-157
- Negative