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Testing Status of Dacarbazine 10840-H

CASRN: 4342-03-4

Formula: C6-H10-N6-O

Synonyms/Common Names

  • DIC
  • 1H-Imidazole-4-carboxamide, 5-(3,3-dimethyl-1-triazenyl)-

Short-Term Toxicity

  • 14-Day (Intraperitoneal Injection)  (C04717)  Completed 
    • Rats: Sprague Dawley; Mice: Swiss
  • 13-Week (Intraperitoneal Injection)  (C04717)  Completed 
    • Rats: Sprague Dawley; Mice: Swiss

Long-Term Carcinogenicity

  • 2-Year (Intraperitoneal Injection)  (C04717)  Completed 
    •   (Peer Review Approval NA) Citation: EK Weisburger, Bioassay Program for Carcinogenic Hazards of Cancer Chemotherapeutic Agents. Cancer 40:1935-1949 (1977)
    • Rats: Sprague Dawley; Mice: Swiss

Genetic Toxicology

  • Salmonella  (003765)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K. Salmonella mutagenicity tests: IV. Results from the testing of 300 chemicals. Environ Mol Mutagen. 1988;11 Suppl 12:1-157
    •  Positive 
  • Salmonella  (685439)  Completed 
    •  Positive