Testing Status of Lindane 10865-T

CASRN: 58-89-9

Formula: C6-H6-Cl6

Synonyms/Common Names

• (1alpha,2alpha,3beta,4alpha,5alpha,6beta)-1,2,3,4,5,6-hexachloro-cyclohexane (9CI)
• Gama-HCH
• Gamma-BHC

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C00204)  Completed 
  • Rats: Osborne Mendel; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C00204)  Completed 
  • Rats: Osborne Mendel; Mice: B6C3F1
  • Dose: R: 0, 160, 2560, M: 0, 40, 1280 PPM/5 PER GROUP.

Long-Term Carcinogenicity

• 2-Year (Dosed-Feed)  (C00204)  Completed 
  • TR-014 (NIH Number: 77-814)  (Peer Review Approval 07/25/1977A )
    Bioassay of Lindane for Possible Carcinogenicity (CASRN 58-89-9)
  • Rats: Osborne Mendel; Mice: B6C3F1
  • Carcinogenesis Results
    • Male Rats Negative 
    • Female Rats Negative 
    • Male Mice Negative 
    • Female Mice Negative 
  • Dose: MR: 0, 236, 472 (AVG), FR: 0, 135, 270 (AVG), M: 0, 80, 160 PPM/50 PER GROUP.

Special Studies

• C. elegans  (S0929)  Completed 
  • C. elegans
  • Dose: feed (0, .025, .032, .04, .05, .063, .079, .1, .13, .16, .20, .25) mM 11/02/06repro (0, .01, .016, .025, .04, .063, .1, .16, .25, .4, .63, 1) mM 02/23/06GROWTH: (0, .01, .016, .025, .04, .063, .1, .16, .25, .4, .63, 1) mM 06/27/07.

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (931320)  Completed 
  • Sister Chromatid Exchange Negative 
  • Chromosome Aberrations Negative 
• Mouse Lymphoma  (849017)  Completed 
  • Mice
  •  Equivocal 
• Salmonella  (946710)  Completed 
  • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
  •  Negative