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Testing Status of Lasiocarpine 10868-F

CASRN: 303-34-4

Formula: C21-H33-N-O7

Synonyms/Common Names

  • 7-((2,3-Dihydroxy-2-(1-methoxyethyl)-3-methyl-1-oxobutoxy)methyl)-2-butanoic acid (9CI)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C01478)  Completed 
    • Rats: F344/N
  • 13-Week (Dosed-Feed)  (C01478)  Completed 
    • Rats: F344/N
    • Dose: 0, 5, or 160 ppm/30 per group.

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C01478)  Completed 
    • TR-039 (NIH Number: 78-839)  (Peer Review Approval 11/28/1978A )
      Bioassay of Lasiocarpine for Possible Carcinogenicity (CASRN 303-34-4)
    • Rats: F344/N
    • Dose: 0, 7, 15, or 30 ppm/48 per group.
    • Carcinogenesis Results
      • Male Rats Positive 
      • Female Rats Positive 

Genetic Toxicology

  • Drosophila  (005545)  Completed 
    • Citation: Yoon JS, Mason JM, Valencia R, Woodruff RC, Zimmering S. Chemical mutagenesis testing in Drosophila. IV. Results of 45 coded compounds tested for the National Toxicology Program. Environ Mutagen. 1985;7(3):349-67. doi: 10.1002/em.2860070310
    • Sex-Linked Recessive Lethal Positive 
    • Reciprocal Translocation Positive 
  • In Vitro Cytogenetics (CA/SCE)  (256879)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Micronucleus  (A44011)  Completed 
    • Female Positive 
  • Salmonella  (270072)  Completed 
    • Citation: Haworth S, Lawlor T, Mortelmans K, Speck W, Zeiger E. Salmonella mutagenicity test results for 250 chemicals. Environ Mutagen. 1983;5 Suppl 1:1-142
    •  Positive