Testing Status of Lasiocarpine 10868-F

CASRN: 303-34-4

Formula: C21-H33-N-O7

Synonyms/Common Names

• 7-((2,3-Dihydroxy-2-(1-methoxyethyl)-3-methyl-1-oxobutoxy)methyl)-2-butanoic acid (9CI)

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C01478)  Completed 
  • Rats: F344/N
• 13-Week (Dosed-Feed)  (C01478)  Completed 
  • Rats: F344/N
  • Dose: 0, 5, or 160 ppm/30 per group.

Long-Term Carcinogenicity

• 2 years (Dosed-Feed)  (C01478)  Completed 
  • TR-039 (NIH Number: 78-839)  (Peer Review Approval 11/28/1978A )
    Bioassay of Lasiocarpine for Possible Carcinogenicity (CASRN 303-34-4)
  • Rats: F344/N
  • Carcinogenesis Results
    • Male Rats Positive 
    • Female Rats Positive 
  • Dose: 0, 7, 15, or 30 ppm/48 per group.

Genetic Toxicology

• Drosophila  (005545)  Completed 
  • Citation: Yoon, J.S., Mason, J.M., Valencia, R., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: IV. Results of 45 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 349-367
  • Sex-Linked Recessive Lethal Positive 
  • Reciprocal Translocation Positive 
• In Vitro Cytogenetics (CA/SCE)  (256879)  Completed 
  • Sister Chromatid Exchange Positive 
  • Chromosome Aberrations Positive 
• Micronucleus  (A44011)  Completed 
  • Female Positive 
• Salmonella  (270072)  Completed 
  • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
  •  Positive