Testing Status of Isobutyl nitrite 10869-J
CASRN: 542-56-3
Formula: C4-H9-N-O2
Synonyms/Common Names
- Isobutyl nitrite (AIDS)
- Nitrous acid, 2-methylpropyl ester (9CI)
Short-Term Toxicity
- 2 weeks (Inhalation)
(C61052B)
Completed
- Rats: F344/N; Mice: B6C3F1
- 13 weeks (Inhalation)
(C61052B)
Completed
- Rats: F344/N; Mice: B6C3F1
- Dose: R&M: 10, 25, 75, 150, OR 300 PPM; 6 HR/DAY, 5 DAY/WEEK, 10/GROUP.
Long-Term Carcinogenicity
- 2 years (Inhalation)
(C61052B)
Completed
- TR-448 (NIH Number: 96-3364)
(Peer Review Approval 11/29/1994A )
Toxicology and Carcinogenesis Studies of Isobutyl Nitrite in F344/N Rats and B6C3F1 Mice (Inhalation Studies) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Clear Evidence
- Female Rats Clear Evidence
- Male Mice Some Evidence
- Female Mice Some Evidence
- Dose: R&M: 0, 37, 75, OR 150 PPM.
- TR-448 (NIH Number: 96-3364)
(Peer Review Approval 11/29/1994A )
Genetic Toxicology
- Drosophila
(399025)
Completed
- Citation: Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702
- Reciprocal Translocation/Sex-Linked Recessive Lethal Negative
- In Vitro Cytogenetics (CA/SCE)
(016060)
Completed
- Sister Chromatid Exchange Positive
- Chromosome Aberrations Positive
- In Vitro Cytogenetics (CA/SCE)
(841266)
Completed
- Sister Chromatid Exchange Positive
- Chromosome Aberrations Positive
- Micronucleus
(A87798)
Completed
- Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
- Mice: B6C3F1
- Male Positive
- Female Positive
- Salmonella
(234350)
Completed
- Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
- Positive
- Salmonella
(507924)
Completed
- Positive
- Salmonella
(983397)
Completed
- Positive