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Testing Status of 1,1,2,2-Tetrachloroethane 10915-J

CASRN: 79-34-5

Formula: C2-H2-Cl4

Synonyms/Common Names

  • Acetylene tetrachloride
  • Acetylenetetrachloride
  • TCE

Short-Term Toxicity

  • 14-Day (Gavage)  (C03554A)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
  • 2 weeks (Microencapsulation in Feed)  (C03554B)  Completed 
    • TOX-49 (NIH Number: 04-4414)
      Toxicity Studies of 1,1,2,2-Tetrachloroethane (CASRN 79-34-5) Administered in Microcapsules in Feed to F344/N Rats and B6C3F1 Mice
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 3325, 6650, 13300, 26600, OR 53200 PPM (5/SEX/SPECIES/GROUP).
  • 2 weeks (Gavage)  (C03554C)  Completed 
    • TOX-49 (NIH Number: 04-4414)
      Toxicity Studies of 1,1,2,2-Tetrachloroethane (CASRN 79-34-5) Administered in Microcapsules in Feed to F344/N Rats and B6C3F1 Mice
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 135, 270, OR 540 MG/KG M: 0, 337.5, 675, OR 1350 MG/KG (50/SEX/SPECIES).
  • 13-Week (Gavage)  (C03554A)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Dose: R: 0, 56, 562, M: 0, 32, 136 MG/KG/10 PER GROUP.
  • 14 weeks (Microencapsulation in Feed)  (C03554E)  Completed 
    • TOX-49 (NIH Number: 04-4414)  (Tox Peer Review 05/23/2002A )
      Toxicity Studies of 1,1,2,2-Tetrachloroethane (CASRN 79-34-5) Administered in Microcapsules in Feed to F344/N Rats and B6C3F1 Mice
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: UNTREATED CONTROLS; VEHICLE CONTROLS; 268, 589, 1180, 2300 OR 4600 PPM (RATS) OR 589, 1120, 2300, 4550 OR 9100 PPM (MICE) 10/SEX/SPECIES/GROUP..

Long-Term Carcinogenicity

  • 2-Year (Gavage)  (C03554A)  Completed 
    • TR-027 (NIH Number: 78-827)  (Peer Review Approval 09/26/1977A )
      Bioassay of 1,1,2,2-Tetrachloroethane for Possible Carcinogenicity (CASRN 79-34-5)
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Dose: FR: 0, 43, 76 (AVG), MR: 0, 62, 108 (AVG), M: 0, 142, 284 (AVG) MG/KG/50 PER GROUP.
    • Carcinogenesis Results
      • Male Rats Equivocal 
      • Female Rats Negative 
      • Male Mice Positive 
      • Female Mice Positive 

Genetic Toxicology

  • Drosophila  (959130)  Completed 
    • Citation: Woodruff RC, Mason JM, Valencia R, Zimmering S. Chemical mutagenesis testing in Drosophila. V. Results of 53 coded compounds tested for the National Toxicology Program. Environ Mutagen. 1985;7(5):677-702. doi: 10.1002/em.2860070507
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • In Vitro Cytogenetics (CA/SCE)  (838914)  Completed 
    • Citation: Galloway SM, Armstrong MJ, Reuben C, Colman S, Brown B, Cannon C, Bloom AD, Nakamura F, Ahmed M, Duk S, Rimpo J, Margolin B, Resnick M, Anderson B, and Zeiger E. Chromosome aberrations and sister chromatid exchanges in Chinese hamster ovary cells: evaluations of 108 chemicals. Environ Mol Mutagen. 1987;10 Suppl 10:1-175. doi: 10.1002/em.2850100502
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Micronucleus  (A72450)  Completed 
    • Mice: B6C3F1
    • Male Positive 
    • Female Positive 
  • Micronucleus  (B72450)  Completed 
    • Mice: B6C3F1
    • Male Equivocal 
    • Female Positive 
  • Mouse Lymphoma  (990809)  Completed 
    • Mice
    •  Negative 
  • Salmonella  (547949)  Completed 
    • Citation: Haworth S, Lawlor T, Mortelmans K, Speck W, Zeiger E. Salmonella mutagenicity test results for 250 chemicals. Environ Mutagen. 1983;5 Suppl 1:1-142
    •  Negative 
  • Salmonella  (866388)  Completed 
    •  Negative 

Organ Systems Toxicity

  • Teratology Pilot Studies (Dosed-Feed)  (TRP91023)  Completed 
    • Female Mice: Swiss CD-1
    • Dose: 0, 4, 7.5, 10.%.
  • 6 to 16 GD Teratology Pilot Studies (Dosed-Feed)  (TRP91028)  Completed 
    • Female Mice: Swiss CD-1
    • Dose: 0, .0125, .05, .1, .2, OR .3 %.
  • 6 to 16 GD Teratology Pilot Studies (Dosed-Feed)  (TRP91029)  Completed 
    • Female Rats: Sprague Dawley
    • Dose: 0, 0.045, 0.135, 0.270, 0.405, OR 0.540%.
  • 6 to 15 GD Teratology Pilot Studies (Dosed-Feed)  (TRP91069)  Completed 
    • Female Mice: Swiss CD-1
    • Dose: 0, .5, 1, 1.5, 2, OR 3%.
  • Teratology Pilot Studies (Gavage)  (TRP92039)  Completed 
    • Rabbits: New Zealand White
    • Dose: 0, 10, 50, 100, 150, 200 MG/KG.
  • Teratology Pilot Studies (Gavage)  (TRP92064)  Completed 
    • Rats
    • Dose: 0, 100, 150, 200, 250 MG/KG.