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Testing Status of Photodieldrin 10937-H

 

CASRN: 13366-73-9

Formula: C12-H8-Cl6-O

Synonyms/Common Names

  • 2,4,6-Metheno-2H-cyclopenta(4,5)pentaleno(1,2-b)oxirene, 2a,3,3,4,5,5a-hexachlorodecahydro-, (1aR,1bR,2S,2aS,4R,5S,5aS,5bS,6S,6aS,7R)-

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C00599)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C00599)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Dose: R: 0, 2.5, 80 (AVG), M: 0, .01, .32 (AVG) PPM/10 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C00599)  Completed 
    • TR-017 (NIH Number: 77-817)  (Peer Review Approval 07/25/1977A )
      Bioassay of Photodieldrin for Possible Carcinogenicity (CASRN 13366-73-9)
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: MR: 0, 5, 10, FR: 0, 3, 4, 7.5 (AVG), M: 0, .32, .64 PPM/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (934568)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Salmonella  (543366)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
    •  Positive