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Testing Status of Diethylene glycol 10993-P

CASRN: 111-46-6

Formula: C4-H10-O3

Synonyms/Common Names

  • 2,2'-Oxydiethanol

Special Studies

  • Absorption Distribution Metabolism Excretion (Gavage; Dosed-Water; Intravenous; Gavage)  (S0219)  Completed 
    • Citation: Mathews JM, Parker MK, Matthews HB. Metabolism and disposition of diethylene glycol in rat and dog. Drug Metab Dispos. 1991 Nov-Dec;19(6):1066-70.Pubmed Abstract
    • Male Rats [R]: F344/N; Female Dogs [D]: Beagles
    • Dose: (gavage) 50 & 5000 mg/kg [R]. (dosed-water) 0.3, 1.0 & 3.0% [R]. (intravenous) 50 mg/kg [R]. (gavage) 500 mg/kg [D].

Genetic Toxicology

  • Salmonella  (248390)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative 

Organ Systems Toxicity

  • continuous exposure, 120 day minimum Continuous Breeding (Legacy) (Dosed-Water)  (RACB83086)  Completed 
    • Male and Female Mice: Swiss
    • Dose: N/A; 0, .35, 1.75, 3.5%; N/A; N/A.
  • 6 to 15 GD Conventional Teratology (Gavage)  (TER89001)  Completed 
    • Female Mice: Swiss CD-1
    • Dose: 0, 1250, 5000, 10000 MG/KG/DAY.
    • Mice Maternal Positive 
    • Mice Fetal Positive 
  • 8 consecutive days (MTD PHASE), 7 to 14 GD (reproductive phase) Short-Term in vivo Repro. Tox. (Gavage)  (T0075A)  Completed 
    • Citation: Screening of Priority Chemicals for Potential Reproductive Hazard
    • Female Mice: Swiss
    • Dose: 11, 180 MG(10ML UNDILUTED)/KG BODY WEIGHT.