Testing Status of Diethylene glycol 10993-P

Absorption Distribution Metabolism Excretion (Gavage; Dosed-Water; Intravenous; Gavage) (S0219) Completed
- Citation: Mathews JM, Parker MK, Matthews HB. Metabolism and disposition of diethylene glycol in rat and dog. Drug Metab Dispos. 1991 Nov-Dec;19(6):1066-70.Pubmed Abstract
- Male Rats [R]: F344/N; Female Dogs [D]: Beagles
- Dose: (gavage) 50 & 5000 mg/kg [R]. (dosed-water) 0.3, 1.0 & 3.0% [R]. (intravenous) 50 mg/kg [R]. (gavage) 500 mg/kg [D].

Salmonella (248390) Completed
- Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
- Negative

continuous exposure, 120 day minimum Continuous Breeding (Legacy) (Dosed-Water) (RACB83086) Completed
- Male and Female Mice: Swiss
- Dose: N/A; 0, .35, 1.75, 3.5%; N/A; N/A.
6 to 15 GD Conventional Teratology (Gavage) (TER89001) Completed
- Female Mice: Swiss CD-1
- Dose: 0, 1250, 5000, 10000 MG/KG/DAY.
- Mice Maternal Positive
- Mice Fetal Positive
8 consecutive days (MTD PHASE), 7 to 14 GD (reproductive phase) Short-Term in vivo Repro. Tox. (Gavage) (T0075A) Completed
- Citation: Screening of Priority Chemicals for Potential Reproductive Hazard
- Female Mice: Swiss
- Dose: 11, 180 MG(10ML UNDILUTED)/KG BODY WEIGHT.