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Testing Status of 3,3'-Dimethylbenzidine 11045-W

CASRN: 119-93-7

Formula: C14-H16-N2

Synonyms/Common Names

  • o-Tolidine

Special Studies

  • Metabolism (Dosed-Feed)  (S0146)  Completed 
    • Citation: Lynn RK, Donielson DW, Ilias AM, Kennish JM, Wong K, Matthews HB. Metabolism of bisazobiphenyl dyes derived from benzidine, 3,3'-dimethylbenzidine or 3,3'-dimethoxybenzidine to carcinogenic aromatic amines in the dog and rat. Toxicol Appl Pharmacol. 1980 Nov;56(2):248-58.Pubmed Abstract
    • Rats [R]; Dogs [D]

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (520009)  Completed 
    • Citation: Galloway SM, Armstrong MJ, Reuben C, Colman S, Brown B, Cannon C, Bloom AD, Nakamura F, Ahmed M, Duk S, Rimpo J, Margolin B, Resnick M, Anderson B, and Zeiger E. Chromosome aberrations and sister chromatid exchanges in Chinese hamster ovary cells: evaluations of 108 chemicals. Environ Mol Mutagen. 1987;10 Suppl 10:1-175. doi: 10.1002/em.2850100502
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Mouse Lymphoma  (570901)  Completed 
    • Citation: Myhr BC, Caspary WJ. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: intralaboratory results for sixty-three coded chemicals tested at Litton Bionetics, Inc. Environ Mol Mutagen. 1988;12 Suppl 13:103-94. doi: 10.1002/em.2860120505
    • Mice
  • Mouse Lymphoma  (576643)  Completed 
    • Citation: Mitchell AD, Rudd CJ, Caspary WJ. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: intralaboratory results for sixty-three coded chemicals tested at SRI International. Environ Mol Mutagen. 1988;12 Suppl 13:37-101. doi: 10.1002/em.2860120504
    • Mice
  • Salmonella Reduction  (715943)  Completed 
    • Citation: Reid TM, Morton KC, Wang CY, King CM. Mutagenicity of azo dyes following metabolism by different reductive/oxidative systems. Environ Mutagen. 1984;6(5):705-17. doi: 10.1002/em.2860060508
    •  Positive 
  • Salmonella  (371333)  Completed 
    •  Positive 
  • Salmonella  (759722)  Completed 
    • Citation: Haworth S, Lawlor T, Mortelmans K, Speck W, Zeiger E. Salmonella mutagenicity test results for 250 chemicals. Environ Mutagen. 1983;5 Suppl 1:1-142
    •  Positive