Testing Status of 2-Butoxyethanol (ethylene glycol monobutyl ether) 11135-T
CASRN: 111-76-2
Formula: C6-H14-O2
Synonyms/Common Names
- Butoxyethonol
- 2-Butoxyethanol
- EGMBE
Short-Term Toxicity
- 2 weeks (Dosed-Water)
(C62077)
Completed
- TOX-26 (NIH Number: 93-3349)
(Peer Review Approval 12/01/1992A )
Toxicity Studies of Ethylene Glycol Ethers 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CASRNs 109-86-4, 110-80-5, 111-76-2) Administered in Drinking Water to F344/N Rats and B6C3F1 Mice - Rats: F344/N; Mice: B6C3F1
- TOX-26 (NIH Number: 93-3349)
(Peer Review Approval 12/01/1992A )
- 2 weeks (Inhalation)
(C62077D)
Completed
- Rats: F344/N; Mice: B6C3F1
- Dose: R&M: 0, 31, 62.5, 125, 250, 500, OR 1000 PPM; 5/SEX/SPECIES/GROUP.
- 13 weeks (Dosed-Water)
(C62077)
Completed
- TOX-26 (NIH Number: 93-3349)
Toxicity Studies of Ethylene Glycol Ethers 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CASRNs 109-86-4, 110-80-5, 111-76-2) Administered in Drinking Water to F344/N Rats and B6C3F1 Mice - Rats: F344/N; Mice: B6C3F1
- Dose: CORE STUDY: R&M: 0, 750, 1500, 3000, 4500, 6000 PPM/10 PER GROUP; STOP STUDY: R: 0, 1500, 3000, 6000 PPM/30 PER GROUP.
- TOX-26 (NIH Number: 93-3349)
- 8 weeks (Dosed-Water)
(C62077C)
Completed
- TOX-26 (NIH Number: 93-3349)
Toxicity Studies of Ethylene Glycol Ethers 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CASRNs 109-86-4, 110-80-5, 111-76-2) Administered in Drinking Water to F344/N Rats and B6C3F1 Mice - Rats: F344/N
- Dose: R: 0, 3000, 6000 PPM/20 PER GROUP.
- TOX-26 (NIH Number: 93-3349)
- 13 weeks (Inhalation)
(C62077D)
Completed
- Rats: F344/N; Mice: B6C3F1
- Dose: R&M: 0, 31, 62.5, 125, 250, OR 500 PPM; 10/SEX/SPECIES/GROUP.
Long-Term Carcinogenicity
- 2 years (Inhalation)
(C62077D)
Completed
- TR-484 (NIH Number: 00-3974)
(Peer Review Approval 10/30/1998A )
Toxicology and Carcinogenesis Studies of 2-Butoxyethanol (CASRN 111-76-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) - Rats: F344/N; Mice: B6C3F1
- Dose: R: 0, 31, 62.5, OR 125 PPM M: 0, 62.5, 125, OR 250 PPM; 50/SEX/SPECIES.
- Carcinogenesis Results
- Male Rats No Evidence
- Female Rats Equivocal Evidence
- Male Mice Some Evidence
- Female Mice Some Evidence
- TR-484 (NIH Number: 00-3974)
(Peer Review Approval 10/30/1998A )
Special Studies
- Absorption Distribution Metabolism Excretion (Gavage)
(S0719)
Completed
- Citation: Ghanayem BI, Burka LT, Sanders JM, Matthews HB. Metabolism and disposition of ethylene glycol monobutyl ether (2-butoxyethanol) in rats. Drug Metab Dispos. 1987 Jul-Aug;15(4):478-84.Pubmed Abstract
- Male Rats [R]: F344/N
- Absorption Distribution Metabolism Excretion (Topical Application)
(S0777)
Completed
- Citation: Sabourin PJ, Medinsky MA, Thurmond F, Birnbaum LS, Henderson RF. Effect of dose on the disposition of methoxyethanol, ethoxyethanol, and butoxyethanol administered dermally to male F344/N rats. Fundam Appl Toxicol. 1992 Jul;19(1):124-32.Pubmed Abstract
- Male Rats [R]: F344/N
- Absorption Distribution Metabolism Excretion (Dosed-Water)
(S0778)
Completed
- Citation: Medinsky MA, Singh G, Bechtold WE, Bond JA, Sabourin PJ, Birnbaum LS, Henderson RF. Disposition of three glycol ethers administered in drinking water to male F344/N rats. Toxicol Appl Pharmacol. 1990 Mar 1;102(3):443-55.Pubmed Abstract
- Male Rats [R]: F344/N
- Dose: (dosed-water) 290, 860, 2590 ppm [R].
- Mechanisms (Gavage)
(S0718)
Completed
- Citation: Ghanayem BI, Sanchez IM, Matthews HB. Development of tolerance to 2-butoxyethanol-induced hemolytic anemia and studies to elucidate the underlying mechanisms. Toxicol Appl Pharmacol. 1992 Feb;112(2):198-206.Pubmed Abstract
- Male Rats [R]: F344/N
- Metabolism (Gavage)
(S0387)
Completed
- Citation: Ghanayem BI, Blair PC, Thompson MB, Maronpot RR, Matthews HB. Effect of age on the toxicity and metabolism of ethylene glycol monobutyl ether (2-butoxyethanol) in rats. Toxicol Appl Pharmacol. 1987 Nov;91(2):222-34.Pubmed Abstract
- Male Rats [R]: F344/N
- Dose: (gavage) 32, 63, 125, 250 & 500 mg/kg [R].
- Metabolism (Inhalation)
(S0722)
Completed
- Citation: Sabourin PJ, Medinsky MA, Birnbaum LS, Griffith WC, Henderson RF. Effect of exposure concentration on the disposition of inhaled butoxyethanol by F344 rats. Toxicol Appl Pharmacol. 1992 Jun;114(2):232-8.Pubmed Abstract
- Male Rats [R]: F344/N
- Other (Gavage)
(S0717)
Completed
- Citation: Ghanayem BI. Metabolic and cellular basis of 2-butoxyethanol-induced hemolytic anemia in rats and assessment of human risk in vitro. Biochem Pharmacol. 1989 May 15;38(10):1679-84.Pubmed Abstract
- Male Rats [R]: F344/N; Human (Cell Lines) [HU]
- Other (Gavage)
(S0721)
Completed
- Citation: Ghanayem BI, Ward SM, Blair PC, Matthews HB. Comparison of the hematologic effects of 2-butoxyethanol using two types of hematology analyzers. Toxicol Appl Pharmacol. 1990 Nov;106(2):341-5.Pubmed Abstract
- Male Rats [R]: F344/N
- Toxicokinetic Study (Gavage)
(S0720)
Completed
- Citation: Ghanayem BI, Sanders JM, Clark AM, Bailer J, Matthews HB. Effects of dose, age, inhibition of metabolism and elimination on the toxicokinetics of 2-butoxyethanol and its metabolites. J Pharmacol Exp Ther. 1990 Apr;253(1):136-43.Pubmed Abstract
- Male Rats [R]: F344/N
- Dose: (gavage) 31.25, 62.5, 125.0 mg/kg [R].
Genetic Toxicology
- In Vitro Cytogenetics (CA/SCE)
(029931)
Completed
- Sister Chromatid Exchange Negative
- Chromosome Aberrations Negative
- Micronucleus
(A89412)
Completed
- Mice: B6C3F1
- Male Negative
- Micronucleus
(A96057)
Completed
- Rats: Fischer 344
- Male Negative
- Salmonella
(006665)
Completed
- Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K. Salmonella mutagenicity tests: V. Results from the testing of 311 chemicals. Environ Mol Mutagen. 1992;19 Suppl 21:2-141. doi: 10.1002/em.2850190603
- Negative
Organ Systems Toxicity
- continuous exposure, 120 day minimum Continuous Breeding (Legacy) (Dosed-Water)
(RACB85053)
Completed
- Male and Female Mice: Swiss
- Dose: N/A; 0, .5, 1.0, 2.0%; N/A; N/A.
- 7 to 16 GD Conventional Teratology (Topical Application)
(T0076B)
Completed
- Female Rats: Sprague Dawley
- Dose: 0.12, 0.35 ML 4 TIMES/DAY.
- 9 to 11 GD & 11 to 13 GD Conventional Teratology (Gavage)
(TER88076)
Completed
- Female Rats: F344/N
- Dose: GESTATION DAYS 9-11: 0, 30, 100, & 200 MG/KG/DAY. GESTATION DAYS 11-13: 0, 30, 100, AND 300 MG/KG/DAY.
- Rats Maternal Positive
- Rats Fetal Positive
- 11 to 13 GD Conventional Teratology (Gavage)
(TER88141)
Completed
- Rats: F344/N
- Dose: ** 0, 30, 100, 300 PPM.
- 8 consecutive days (MTD PHASE), 7 to 14 GD (reproductive phase) Short-Term in vivo Repro. Tox. (Gavage)
(T0076A)
Completed
- Citation: Determination of the Reproductive Effects in Mice of Nine Selected Chemicals
- Female Mice: Swiss
- Dose: 1180 MG/KG BD WT.