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Testing Status of 2-Butoxyethanol (ethylene glycol monobutyl ether) 11135-T

 

CASRN: 111-76-2

Formula: C6-H14-O2

Synonyms/Common Names

  • Butoxyethonol
  • 2-Butoxyethanol
  • EGMBE

Short-Term Toxicity

  • 2 weeks (Dosed-Water)  (C62077)  Completed 
    • TOX-26 (NIH Number: 93-3349)  (Peer Review Approval 12/01/1992A )
      Toxicity Studies of Ethylene Glycol Ethers 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CASRNs 109-86-4, 110-80-5, 111-76-2) Administered in Drinking Water to F344/N Rats and B6C3F1 Mice
    • Rats: F344/N; Mice: B6C3F1
  • 2 weeks (Inhalation)  (C62077D)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 31, 62.5, 125, 250, 500, OR 1000 PPM; 5/SEX/SPECIES/GROUP.
  • 13 weeks (Dosed-Water)  (C62077)  Completed 
    • TOX-26 (NIH Number: 93-3349)
      Toxicity Studies of Ethylene Glycol Ethers 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CASRNs 109-86-4, 110-80-5, 111-76-2) Administered in Drinking Water to F344/N Rats and B6C3F1 Mice
    • Rats: F344/N; Mice: B6C3F1
    • Dose: CORE STUDY: R&M: 0, 750, 1500, 3000, 4500, 6000 PPM/10 PER GROUP; STOP STUDY: R: 0, 1500, 3000, 6000 PPM/30 PER GROUP.
  • 8 weeks (Dosed-Water)  (C62077C)  Completed 
    • TOX-26 (NIH Number: 93-3349)
      Toxicity Studies of Ethylene Glycol Ethers 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CASRNs 109-86-4, 110-80-5, 111-76-2) Administered in Drinking Water to F344/N Rats and B6C3F1 Mice
    • Rats: F344/N
    • Dose: R: 0, 3000, 6000 PPM/20 PER GROUP.
  • 13 weeks (Inhalation)  (C62077D)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 31, 62.5, 125, 250, OR 500 PPM; 10/SEX/SPECIES/GROUP.

Long-Term Carcinogenicity

  • 2 years (Inhalation)  (C62077D)  Completed 
    • TR-484 (NIH Number: 00-3974)  (Peer Review Approval 10/30/1998A )
      Toxicology and Carcinogenesis Studies of 2-Butoxyethanol (CASRN 111-76-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats Equivocal Evidence 
      • Male Mice Some Evidence 
      • Female Mice Some Evidence 
    • Dose: R: 0, 31, 62.5, OR 125 PPM M: 0, 62.5, 125, OR 250 PPM; 50/SEX/SPECIES.

Special Studies

  • Absorption Distribution Metabolism Excretion (Gavage)  (S0719)  Completed 
    • Citation: Ghanayem BI, Burka LT, Sanders JM, Matthews HB. Metabolism and disposition of ethylene glycol monobutyl ether (2-butoxyethanol) in rats. Drug Metab Dispos. 1987 Jul-Aug;15(4):478-84.Pubmed Abstract
    • Male Rats: F344/N
  • Absorption Distribution Metabolism Excretion (Topical Application)  (S0777)  Completed 
    • Citation: Sabourin PJ, Medinsky MA, Thurmond F, Birnbaum LS, Henderson RF. Effect of dose on the disposition of methoxyethanol, ethoxyethanol, and butoxyethanol administered dermally to male F344/N rats. Fundam Appl Toxicol. 1992 Jul;19(1):124-32.Pubmed Abstract
    • Male Rats: F344/N
  • Absorption Distribution Metabolism Excretion (Dosed-Water)  (S0778)  Completed 
    • Citation: Medinsky MA, Singh G, Bechtold WE, Bond JA, Sabourin PJ, Birnbaum LS, Henderson RF. Disposition of three glycol ethers administered in drinking water to male F344/N rats. Toxicol Appl Pharmacol. 1990 Mar 1;102(3):443-55.Pubmed Abstract
    • Male Rats: F344/N
    • Dose: 290, 860, 2590 ppm.
  • Mechanisms (Gavage)  (S0718)  Completed 
    • Citation: Ghanayem BI, Sanchez IM, Matthews HB. Development of tolerance to 2-butoxyethanol-induced hemolytic anemia and studies to elucidate the underlying mechanisms. Toxicol Appl Pharmacol. 1992 Feb;112(2):198-206.Pubmed Abstract
    • Male Rats: F344/N
  • Metabolism (Gavage)  (S0387)  Completed 
    • Citation: Ghanayem BI, Blair PC, Thompson MB, Maronpot RR, Matthews HB. Effect of age on the toxicity and metabolism of ethylene glycol monobutyl ether (2-butoxyethanol) in rats. Toxicol Appl Pharmacol. 1987 Nov;91(2):222-34.Pubmed Abstract
    • Male Rats: F344/N
    • Dose: 32, 63, 125, 250 & 500 mg/kg.
  • Metabolism (Inhalation)  (S0722)  Completed 
    • Citation: Sabourin PJ, Medinsky MA, Birnbaum LS, Griffith WC, Henderson RF. Effect of exposure concentration on the disposition of inhaled butoxyethanol by F344 rats. Toxicol Appl Pharmacol. 1992 Jun;114(2):232-8.Pubmed Abstract
    • Male Rats: F344/N
  • Other (Gavage)  (S0717)  Completed 
    • Citation: Ghanayem BI. Metabolic and cellular basis of 2-butoxyethanol-induced hemolytic anemia in rats and assessment of human risk in vitro. Biochem Pharmacol. 1989 May 15;38(10):1679-84.Pubmed Abstract
    • Male Rats: F344/N; Human (Cell Lines)
  • Other (Gavage)  (S0721)  Completed 
    • Citation: Ghanayem BI, Ward SM, Blair PC, Matthews HB. Comparison of the hematologic effects of 2-butoxyethanol using two types of hematology analyzers. Toxicol Appl Pharmacol. 1990 Nov;106(2):341-5.Pubmed Abstract
    • Male Rats: F344/N
  • Toxicokinetic Study (Gavage)  (S0720)  Completed 
    • Citation: Ghanayem BI, Sanders JM, Clark AM, Bailer J, Matthews HB. Effects of dose, age, inhibition of metabolism and elimination on the toxicokinetics of 2-butoxyethanol and its metabolites. J Pharmacol Exp Ther. 1990 Apr;253(1):136-43.Pubmed Abstract
    • Male Rats: F344/N
    • Dose: 31.25, 62.5, 125.0 mg/kg.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (029931)  Completed 
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Micronucleus  (A89412)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Micronucleus  (A96057)  Completed 
    • Rats: Fischer 344
    • Male Negative 
  • Salmonella  (006665)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Negative 

Organ Systems Toxicity

  • continuous exposure, 120 day minimum Continuous Breeding (Legacy) (Dosed-Water)  (RACB85053)  Completed 
    • Male and Female Mice: Swiss
    • Dose: N/A; 0, .5, 1.0, 2.0%; N/A; N/A.
  • 7 to 16 GD Conventional Teratology (Topical Application)  (T0076B)  Completed 
    • Female Rats: Sprague Dawley
    • Dose: 0.12, 0.35 ML 4 TIMES/DAY.
  • 9 to 11 GD & 11 to 13 GD Conventional Teratology (Gavage)  (TER88076)  Completed 
    • Female Rats: F344/N
    • Rats Maternal Positive 
    • Rats Fetal Positive 
    • Dose: GESTATION DAYS 9-11: 0, 30, 100, & 200 MG/KG/DAY. GESTATION DAYS 11-13: 0, 30, 100, AND 300 MG/KG/DAY.
  • 11 to 13 GD Conventional Teratology (Gavage)  (TER88141)  Completed 
    • Rats: F344/N
    • Dose: ** 0, 30, 100, 300 PPM.
  • 8 consecutive days (MTD PHASE), 7 to 14 GD (reproductive phase) Short-Term in vivo Repro. Tox. (Gavage)  (T0076A)  Completed 
    • Citation: Determination of the Reproductive Effects in Mice of Nine Selected Chemicals
    • Female Mice: Swiss
    • Dose: 1180 MG/KG BD WT.