Testing Status of Phenolic Benzotriazoles (Octrizole) 12005

CASRN: 3147-75-9

Formula: C20-H25-N3-O

Synonyms/Common Names

• 2-(2H-Benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol
• PBZT

Secondary:

• BENZOTRIAZOLES - Phenolic Benzotriazoles

Short-Term Toxicity

• 14 days (Gavage)  (C12005)  Data in Review 
  • Benzotriazole Class
  • Rats: Harlan Sprague-Dawley
  • Dose: Male rats: 0, 30, 100, 300, or 1000 mg/kg in 0.5% aqueous methylcellulose by gavage.

Special Studies

• Single day Toxicokinetic Study (Gavage; Intravenous)  (K12005)  Completed 
  • Citation: Waidyanatha S, Mutlu E, Gibbs S, Pierfelice J, Smith JP, Burback B, Blystone CT. Phenolic benzotriazoles: a class comparison of toxicokinetics of ultraviolet-light absorbers in male rats. Xenobiotica. 2021 Jul;51(7):831-841. doi: https://doi.org/10.1080/00498254.2021.1927239. Epub 2021 May 24.Pubmed Abstract
  • Male Rats: Harlan Sprague-Dawley
  • Dose: 30 mg/kg. 30, 300 mg/kg.

Genetic Toxicology

• Micronucleus (Gavage)  (G12005)  Completed 
  • Rats: Harlan Sprague-Dawley