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Testing Status of Vinpocetine 12103

 

CASRN: 42971-09-5

Formula: C22-H26-N2-O2

Synonyms/Common Names

  • Apovincaminic acid ethyl ester
  • Bravinton
  • Cavinton
  • Ceractin
  • Cis-apovincaminic acid ethyl ester
  • Ethyl (+)-apovincaminate
  • Ethyl (+)-cis-apovincaminate
  • Ethyl (3α,16α)-eburnamenine-14-carboxylate
  • Ethyl apovincamin-22-oate
  • Intelectol
  • RGH-4405
  • TCV-3B
  • Vinporal

Special Studies

  • Toxicokinetic Study (Gavage)  (K12103)  Completed 
    • Citation: Waidyanatha S, Toy H, South N, Gibbs S, Mutlu E, Burback B, McIntyre BS, Catlin N. Systemic exposure of vinpocetine in pregnant Sprague Dawley rats following repeated oral exposure: An investigation of fetal transfer. Toxicol Appl Pharmacol. 2018 Jan 1; 338:83-92. doi: 10.1016/j.taap.2017.11.011. Epub 2017 Nov 15.Pubmed Abstract
    • Female Rats: Harlan Sprague-Dawley
    • Dose: 5 and 20 mg/kg.

Genetic Toxicology

  • Comet Assay  (G12103D)  Completed 
    • Definitive
    • Mice: B6C3F1
  • Micronucleus (Gavage)  (G12103B)  Completed 
    • Range-finder male
    • Mice: B6C3F1
  • 3 days Micronucleus (Gavage)  (G12103C)  Completed 
    • Definitive
    • Mice: B6C3F1
  • Micronucleus (Gavage)  (G12103E)  Completed 
    • Human (Cell Lines)
  • Salmonella  (G12103)  Completed 
    •  Negative 

Organ Systems Toxicity

  • GD 6 to GD 20 Conventional Teratology (Gavage)  (R12103B)  Completed 
    • Citation: National Toxicology Program (NTP). 2020. NTP developmental and reproductive toxicity technical report on the prenatal development studies of vinpocetine (CASRN 42971-09-5) in Sprague Dawley (Hsd:Sprague Dawley SD) rats and New Zealand White (Hra:Nzw Spf) rabbits (gavage studies). Research Triangle Park, NC: National Toxicology Program. DART Report 03. https://doi.org/10.22427/NTP-DART-03
    • Female Rats: Harlan Sprague-Dawley
    • Dose: 0, 5, 20 or 60 mg/kg/day; 25/rats per group.
  • GD 6 to GD 20 Teratology Pilot Studies (Gavage)  (R12103)  Completed 
    • Teratology Dose Range Finder (DRF)
    •   (Peer Review Approval 10/18/2019A ) Citation: National Toxicology Program (NTP). 2020. NTP developmental and reproductive toxicity technical report on the prenatal development studies of vinpocetine (CASRN 42971-09-5) in Sprague Dawley (Hsd:Sprague Dawley SD) rats and New Zealand White (Hra:Nzw Spf) rabbits (gavage studies). Research Triangle Park, NC: National Toxicology Program. DART Report 03. https://doi.org/10.22427/NTP-DART-03
    • Female Rats: Harlan Sprague-Dawley
    • Dose: 0, 20, 40, 80, 160, or 320 mg/kg; 10 rats/group.
  • GD 7 to GD 28 Teratology Pilot Studies (Gavage)  (R12103D)  Completed 
    • Investigative Study
    • Citation: National Toxicology Program (NTP). 2020. NTP developmental and reproductive toxicity technical report on the prenatal development studies of vinpocetine (CASRN 42971-09-5) in Sprague Dawley (Hsd:Sprague Dawley SD) rats and New Zealand White (Hra:Nzw Spf) rabbits (gavage studies). Research Triangle Park, NC: National Toxicology Program. DART Report 03. https://doi.org/10.22427/NTP-DART-03
    • Rabbits: New Zealand White
    • Dose: 0, 25, 75, 150, or 300 mg/kg/group; 8 rabbits/group.