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Testing Status of Developmental Neurotoxicity Screening 21005

CASRN: DNTSCREENPHASE1-2

Special Studies

  • 1 year Zebrafish (Aquatic)  (Z21005)  Data in Review 
    • Phase 1 - Zebrafish Developmental Neurotoxicity Assay
    • Zebrafish [ZE]: Danio rerio
  • 1 year Zebrafish (Aquatic)  (Z21005B)  On Test 
    • Phase 2 - Zebrafish Developmental Neurotoxicity Assay
    • Zebrafish [ZE]: Danio rerio

in vitro Testing

  • 1 year Alternate (in vitro)  (V21005)  Data in Review 
    • Phase 1 - Neural Crest Cell Migration Assay
    • Human (Cell Lines): IMR-90
  • 18 months Alternate (in vitro)  (V21005B)  Completed 
    • Phase 1 - Human Neurosphere Assay
    • Human (Cell Lines): hNPC 3D neurospheres
  • 1 year Alternate (in vitro)  (V21005C)  Data in Review 
    • Phase 1 - Proliferation, Apoptosis, and Viability Assay
    • Human (Cell Lines)
  • 1 year Alternate (in vitro)  (V21005D)  Data in Review 
    • Phase 1 - Neurite Outgrowth Assay
    • Human (Cell Lines)
  • 1 year Alternate (in vitro)  (V21005E)  On Test 
    • Phase 1 - Network Formation Assay
    • Rats: Long-Evans
  • 1 year Alternate (in vitro)  (V21005F)  On Test 
    • Phase 1 - Neurite Outgrowth Assay
    • Rats: Long-Evans
  • 1 year Alternate (in vitro)  (V21005G)  On Test 
    • Phase 1 - Synaptogenesis Assay
    • Rats: Long-Evans
  • 18 months Alternate (in vitro)  (V21005H)  On Test 
    • Phase 2 - Neural Crest Cell Migration Assay
    • Human (Cell Lines): IMR-90
  • 18 months Alternate (in vitro)  (V21005I)  On Test 
    • Phase 2 - Human Neurosphere Assay
    • Human (Cell Lines): hNPC 3D neurospheres
  • 1 year Alternate (in vitro)  (V21005J)  On Test 
    • Phase 2 - Proliferation, Apoptosis, and Viability Assay
    • Human (Cell Lines)
  • 1 year Alternate (in vitro) Selected (V21005K)  
    • Phase 2 - Neurite Outgrowth Assay
    • Human (Cell Lines)
  • 1 year Alternate (in vitro)  (V21005L)  On Test 
    • Phase 2 - Network Formation Assay
    • Rats: Long-Evans
  • 1 year Alternate (in vitro) Selected (V21005M)  
    • Phase 2 - Neurite Outgrowth Assay
    • Rats: Long-Evans
  • 1 year Alternate (in vitro)  (V21005N)  On Test 
    • Phase 2 - Synaptogenesis Assay
    • Rats: Long-Evans