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Testing Status of 5-(4-Nitrophenyl)-2,4-pentadien-1-al (NPPD) 2608482

CASRN: 2608-48-2

Formula: C11-H9-N-O3

Synonyms/Common Names

  • NPPD
  • Spy Dust

Short-Term Toxicity

  • 14-Day (Topical Application)  (C87002)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 14-Day (Dosed-Feed)  (C87002B)  Completed 
    • Rats: F344/N; Mice: B6C3F1

Special Studies

  • Absorption Distribution Metabolism Excretion (Gavage; Intravenous; Topical Application)  (S0076)  Completed 
    • Citation: Burka LT, Sanders JM, Kool CP, Kim YC, Matthews HB. Absorption and metabolism of 5-(4-nitrophenyl)-2,4-pentadienal (Spydust). Toxicol Appl Pharmacol. 1987 Jan;87(1):121-6.Pubmed Abstract
    • Male Rats [R]: F344/N; Male Rats [R]
    • Dose: (gavage) 0.8, 8, 80 mg/kg [R]. (intravenous) 0.8 mg/kg [R]. (topical application) 0.01, 0.1, 1 mg/cm [R].

Genetic Toxicology

  • Chromosome Aberrations  (A84710)  Completed 
    • Citation: Zeiger E, Shelby MD, Ivett J, McFee AF. Mutagenicity testing of 5-(4-nitrophenyl)-2,4-pentadien-1-al (spy dust) and its metabolites in vitro and in vivo. Environ Mutagen. 1987;9(3):269-80. doi: 10.1002/em.2860090306
    • Mice
    •  Negative (Nonstandard Protocol) 
  • In Vitro Cytogenetics (CA/SCE)  (073716)  Completed 
    • Citation: Zeiger E, Shelby MD, Ivett J, McFee AF. Mutagenicity testing of 5-(4-nitrophenyl)-2,4-pentadien-1-al (spy dust) and its metabolites in vitro and in vivo. Environ Mutagen. 1987;9(3):269-80. doi: 10.1002/em.2860090306
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Micronucleus  (A63788)  Completed 
    • Citation: Witt KL, Knapton A, Wehr CM, Hook GJ, Mirsalis J, Shelby MD, MacGregor JT. Micronucleated erythrocyte frequency in peripheral blood of B6C3F(1) mice from short-term, prechronic, and chronic studies of the NTP carcinogenesis bioassay program. Environ Mol Mutagen. 2000;36(3):163-94
    • Mice: B6C3F1
    • Female Positive (Nonstandard Protocol) 
  • Sister Chromatid Exchanges  (A84710)  Completed 
    • Citation: Zeiger E, Shelby MD, Ivett J, McFee AF. Mutagenicity testing of 5-(4-nitrophenyl)-2,4-pentadien-1-al (spy dust) and its metabolites in vitro and in vivo. Environ Mutagen. 1987;9(3):269-80. doi: 10.1002/em.2860090306
    • Mice
    • Sister Chromatid  Positive (Nonstandard Protocol)