Testing Status of Methyl vinyl ketone 78944

CASRN: 78-94-4

Formula: C4-H6-O

Synonyms/Common Names

• Acetyl ethylene
• 3-Buten-2-one (8CI)(9CI)
• MVK
• Vinyl methyl ketone

Short-Term Toxicity

• 2 weeks (Inhalation)  (C92005)  Completed 
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R&M: 0, 0.25, 0.5, 1, 2, 4, OR 8 PPM.
• 13 weeks (Inhalation)  (C92005)  Completed 
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R&M: 0, 0.5, 1, OR 2 PPM.

Genetic Toxicology

• Micronucleus  (A80150)  Completed 
  • Rats: Fischer 344
  • Male Equivocal 
• Micronucleus  (A92643)  Completed 
  • Mice: B6C3F1
  • Male Equivocal 
  • Female Negative 
• Salmonella  (876647)  Completed 
  • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K. Salmonella mutagenicity tests: V. Results from the testing of 311 chemicals. Environ Mol Mutagen. 1992;19 Suppl 21:2-141. doi: 10.1002/em.2850190603
  •  Positive