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Testing Status of 1,1-Dichloroethane C04535

CASRN: 75-34-3

Formula: C2-H4-Cl2

Synonyms/Common Names

  • Ethylidene dichloride

Short-Term Toxicity

  • 14-Day (Gavage)  (C04535)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
  • 13-Week (Gavage)  (C04535)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Dose: R: 0, 562, 5620, M: 0, 1000, 10000 MG/KG/5 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Gavage)  (C04535)  Completed 
    • TR-066 (NIH Number: 78-1316)  (Peer Review Approval 01/18/1978A )
      Bioassay of 1,1-Dichloroethane for Possible Carcinogenicity (CASRN 75-34-3)
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Dose: MR: 0, 382, 764 (AVG), FR: 0, 475, 950 (AVG), MM: 0, 1442, 2885 (AVG), FM: 0, 1665, 3331 (AVG) MG/KG/50 PER GROUP.
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Equivocal 
      • Male Mice Negative 
      • Female Mice Equivocal 

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (508873)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Salmonella  (777132)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K. Salmonella mutagenicity tests: V. Results from the testing of 311 chemicals. Environ Mol Mutagen. 1992;19 Suppl 21:2-141. doi: 10.1002/em.2850190603
    •  Negative