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Testing Status of Aloe vera whole leaf extract (native) M030041


Synonyms/Common Names

  • Aloe vera leaf ext.
  • Aloe vera whole leaf extract (nondecolorized)
  • Nondecolorized Aloe vera whole leaf extract
  • Nondecolorized whole leaf extract of Aloe barbadensis Miller (Aloe vera)

Short-Term Toxicity

  • 13 weeks (Dosed-Water)  (C20116B)  Completed 
    • Rats: F344 (NCTR); Mice: B6C3F1 (NCTR)
    • Dose: 0, 1%, or 3% in drinking water.

Long-Term Carcinogenicity

  • 2 years (Dosed-Water)  (C20116B)  Completed 
    • TR-577 (NIH Number: 11-5919)  (Peer Review Approval 04/05/2011A )
      Toxicology and Carcinogenesis Studies of a Nondecolorized Whole Leaf Extract of Aloe Barbadensis Miller (Aloe Vera) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies)
    • Rats: F344 (NCTR); Mice: B6C3F1 (NCTR)
    • Dose: R: 0, 0.5%, 1.0% or 1.5%; M: 0, 1%, 2% or 3%.
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Clear Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
  • 40 weeks (Topical Application)  (C20116D)  Completed 
    • TR-553 (NIH Number: 10-5894)  (Peer Review Approval 02/27/2008A )
      Photococarcinogenesis Study of Aloe Vera [CASRN 481-72-1 (Aloe-emodin)] in SKH-1 Mice (Simulated Solar Light and Topical Application Study)
    • Mice: SKH-1 Hairless
    • Dose: 0, 3%, or 6% compound with simulated solar light exposure.

Genetic Toxicology

  • Salmonella  (G03041)  Completed 
    •  Negative