Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of Aloe vera whole leaf extract (native) M030041

CASRN: ALOEVLEAFEXT

Synonyms/Common Names

  • Aloe vera leaf ext.
  • Aloe vera whole leaf extract (nondecolorized)
  • Nondecolorized Aloe vera whole leaf extract
  • Nondecolorized whole leaf extract of Aloe barbadensis Miller (Aloe vera)

Short-Term Toxicity

  • 13 weeks (Dosed-Water)  (C20116B)  Completed 
    • Rats: F344 (NCTR); Mice: B6C3F1 (NCTR)
    • Dose: 0, 1%, or 3% in drinking water.

Long-Term Carcinogenicity

  • 2 years (Dosed-Water)  (C20116B)  Completed 
    • TR-577 (NIH Number: 11-5919)  (Peer Review Approval 04/05/2011A )
      Toxicology and Carcinogenesis Studies of a Nondecolorized Whole Leaf Extract of Aloe Barbadensis Miller (Aloe Vera) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies)
    • Rats: F344 (NCTR); Mice: B6C3F1 (NCTR)
    • Dose: R: 0, 0.5%, 1.0% or 1.5%; M: 0, 1%, 2% or 3%.
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Clear Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
  • 40 weeks (Topical Application)  (C20116D)  Completed 
    • TR-553 (NIH Number: 10-5894)  (Peer Review Approval 02/27/2008A )
      Photococarcinogenesis Study of Aloe Vera [CASRN 481-72-1 (Aloe-emodin)] in SKH-1 Mice (Simulated Solar Light and Topical Application Study)
    • Mice: SKH-1 Hairless
    • Dose: 0, 3%, or 6% compound with simulated solar light exposure.

Genetic Toxicology

  • Salmonella  (G03041)  Completed 
    •  Negative