Testing Status of Perfluorooctane sulfonic acid (PFOS) M040004

CASRN: 1763-23-1

Formula: C8-H-F17-O3-S

Synonyms/Common Names

• C8 Sulfonate
• Heptadecafluorooctane-1-sulphonic acid
• 1-Octanesulfonic acid, 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluoro
• Perflourooctane sulfonate
• Perfluorooctane sulfonic acid
• PFOS

Short-Term Toxicity

• 28 days (Gavage)  (C20617)  Completed 
  • TOX-96 
    Toxicity Studies of Perfluoroalkyl Sulfonates (Perfluorobutane Sulfonic Acid, Perfluorohexane Sulfonate Potassium Salt, and Perfluorooctane Sulfonic Acid) Administered by Gavage to Sprague Dawley (Hsd:Sprague Dawley SD) Rats (Revised)
  • Rats: Harlan Sprague-Dawley
  • Dose: M&F: 0, 0.312, 0.625, 1.25, 2.5, or 5 mg/kg.

Modified One-Generation

• Dose Range Finding (Gavage)  (MOG04004)  Completed 
  • Dose Range finding
  • Rats: Harlan Sprague-Dawley
  • Dose: 0, 0.5, 1, 1, or 2 mg/kg/day.

Special Studies

• Toxicokinetic Study (Gavage; Intravenous)  (K10076)  Completed 
  • Citation: Huang MC, Dzierlenga AL, Robinson VG, Waidyanatha S, DeVito MJ, Eifrid MA, Granville CA, Gibbs ST, Blystone CR. Toxicokinetics of perfluorobutane sulfonate (PFBS), perfluorohexane-1-sulphonic acid (PFHxS), and perfluorooctane sulfonic acid (PFOS) in male and female Hsd:Sprague Dawley SD rats after intravenous and gavage administration. Toxicol Rep. 2019 Jun 28;6:645-655. doi: https://doi.org/10.1016/j.toxrep.2019.06.016. Erratum in: Toxicol Rep. 2020 Dec 22;8:28-29. Erratum in: Toxicol Rep. 2021 Feb 18;8:365.Pubmed Abstract
  • Male and Female Rats: Fischer 344
  • Dose: 2 mg/kg. 2, 20 mg/kg.

Genetic Toxicology

• Micronucleus  (G04004)  Completed 
  • Rats: Harlan Sprague-Dawley
  • Male Negative 
  • Female Positive 
• Salmonella  (A33826)  Completed 
  •  Negative