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Testing Status of Nanoscale material (Rutile titanium dioxide) M040087

CASRN: 1317-80-2

Formula: O2-Ti

Synonyms/Common Names

  • Rutile titanium dioxide (Nanoscale material)

Short-Term Toxicity

  • 2 weeks (Topical Application)  (C20408)  Completed 
    • Mice: Tg.AC (FVB/N) Hemizygous

Special Studies

  • Absorption Distribution Metabolism Excretion (Intradermal Injection; Topical Application)  (S0975)  Completed 
    • Citation: Gao Y, Gopee NV, Howard PC, Yu LR. Proteomic analysis of early response lymph node proteins in mice treated with titanium dioxide nanoparticles. J Proteomics. 2011 Nov 18;74(12):2745-59. doi: 10.1016/j.jprot.2011.08.009. Epub 2011 Aug 22.Pubmed Abstract
    • Female Mice [M]: SKH-1 Hairless
    • Dose: (intradermal injection) 0.25, 0.5, 1.0, 5, 10 ug [M]. (intradermal injection) 10 ug in saline (no light, UVA light (2 J), SSL (1.0 SED) or 10 ug in oil/water (no light, UVA light (2 J), SSL (1.0 SED) in normal or dermabraded skin [M]. (topical application) 2 mg/cm2 (tape stripped to remove stratum corneum or sunburned skin) [M]. (topical application) 2 mg/cm2 at dorsal or axillalry/inguinal (normal or dermabraded skin) [M].