Absorption Distribution Metabolism Excretion (Intradermal Injection; Topical Application)
Citation: Gao Y, Gopee NV, Howard PC, Yu LR. Proteomic analysis of early response lymph node proteins in mice treated with titanium dioxide nanoparticles. J Proteomics. 2011 Nov 18;74(12):2745-59. doi: 10.1016/j.jprot.2011.08.009. Epub 2011 Aug 22.Pubmed Abstract
Female Mice [M]: SKH-1 Hairless
Dose: (intradermal injection) 0.25, 0.5, 1.0, 5, 10 ug [M]. (intradermal injection) 10 ug in saline (no light, UVA light (2 J), SSL (1.0 SED) or 10 ug in oil/water (no light, UVA light (2 J), SSL (1.0 SED) in normal or dermabraded skin [M]. (topical application) 2 mg/cm2 (tape stripped to remove stratum corneum or sunburned skin) [M]. (topical application) 2 mg/cm2 at dorsal or axillalry/inguinal (normal or dermabraded skin) [M].