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Testing Status of Metal Working Fluids: TRIM® VX M040093

 

CASRN: TRIMVX

Synonyms/Common Names

  • TRIM VX
  • TRIM® VX (metal working fluids)

Short-Term Toxicity

  • 13 weeks (Inhalation)  (C20523)  Completed 
    • Citation: Ryan KR, Cesta MF, Herbert R, Brix A, Cora M, Witt K, Kissling G, Morgan DL. Comparative pulmonary toxicity of inhaled metalworking fluids in rats and mice. Toxicol Ind Health. 2016 Jun
    • Rats: Wistar Han; Mice: B6C3F1
    • Dose: R&M: 0, 25, 50, 100, 200, or 400 mg/m3; 5/sex/species/dose.

Long-Term Carcinogenicity

  • 2 years (Inhalation)  (C20523)  Completed 
    •   (Peer Review Approval 02/16/2016A ) Citation: Ryan KR, Cesta MF, Herbert R, Brix A, Cora M, Witt K, Kissling G, Morgan DL. Comparative pulmonary toxicity of inhaled metalworking fluids in rats and mice. Toxicol Ind Health. 2016 Jun
    • TR-591 (NIH Number: 17-5943)  (Peer Review Approval 02/16/2016A )
      Toxicology and Carcinogenesis Studies of Trim® VX (CASRN TRIMVX) in Wistar Han Rats and B6C3F1 Mice (Inhalation Studies)
    • Rats: Wistar Han; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Equivocal Evidence 
      • Female Rats Equivocal Evidence 
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 
    • Dose: R&M: 0, 10, 30, or 100 mg/m3; 50/sex/species/dose.

Genetic Toxicology

  • Micronucleus  (G04093)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Micronucleus  (G04093B)  Completed 
    • Rats: Wistar Han
    • Male Negative 
    • Female Negative 
  • Salmonella  (A94339)  Completed 
    •  Negative