Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of Metal Working Fluids: TRIM® VX M040093

CASRN: TRIMVX

Synonyms/Common Names

  • TRIM VX
  • TRIM® VX (metal working fluids)

Short-Term Toxicity

  • 13 weeks (Inhalation)  (C20523)  Completed 
    • Citation: Ryan KR, Cesta MF, Herbert R, Brix A, Cora M, Witt K, Kissling G, Morgan DL. Comparative pulmonary toxicity of inhaled metalworking fluids in rats and mice. Toxicol Ind Health. 2016 Jun
    • Rats: Wistar Han; Mice: B6C3F1
    • Dose: R&M: 0, 25, 50, 100, 200, or 400 mg/m3; 5/sex/species/dose.

Long-Term Carcinogenicity

  • 2 years (Inhalation)  (C20523)  Completed 
    •   (Peer Review Approval 02/16/2016A ) Citation: Ryan KR, Cesta MF, Herbert R, Brix A, Cora M, Witt K, Kissling G, Morgan DL. Comparative pulmonary toxicity of inhaled metalworking fluids in rats and mice. Toxicol Ind Health. 2016 Jun
    • TR-591 (NIH Number: 17-5943)  (Peer Review Approval 02/16/2016A )
      Toxicology and Carcinogenesis Studies of Trim® VX (CASRN TRIMVX) in Wistar Han Rats and B6C3F1 Mice (Inhalation Studies)
    • Rats: Wistar Han; Mice: B6C3F1
    • Dose: R&M: 0, 10, 30, or 100 mg/m3; 50/sex/species/dose.
    • Carcinogenesis Results
      • Male Rats Equivocal Evidence 
      • Female Rats Equivocal Evidence 
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 

Genetic Toxicology

  • Micronucleus  (G04093)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Micronucleus  (G04093B)  Completed 
    • Rats: Wistar Han
    • Male Negative 
    • Female Negative 
  • Salmonella  (A94339)  Completed 
    •  Negative