Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of Ionic Liquid: 1-Butyl-3-methylimidazolium Chloride M050050

 

CASRN: 79917-90-1

Formula: C8-H15-Cl-N2

Synonyms/Common Names

  • (Bmim)Cl
  • 1-Butyl-3-methylimidazolium chloride (ionic liquid)

Short-Term Toxicity

  • 14 days (Dosed-Water)  (C05049)  Completed 
    • Rats: Harlan Sprague-Dawley; Mice: B6C3F1
    • Dose: R: 0.3, 1, 3 mg/ml. M: 1, 3, 6 mg/ml. Common Controls for all studies.
  • 90 days (Dosed-Water)  (C50050)  Completed 
    • TOX-103 
      Toxicity Studies of Select Ionic Liquids (1-Ethyl-3-methylimidazolium chloride, 1-Butyl-3-methylimidazolium chloride, 1-Butyl-1-methylpyrrolidinium chloride, and N-butylpyridinium chloride) Administered in Drinking Water to Sprague Dawley (Hsd:Sprague Dawley SD) Rats and B6C3F1/N Mice
    • Rats: Harlan Sprague-Dawley; Mice: B6C3F1/N
    • Dose: R: 0, 0.1, 0.3, or 1 mg/ml. M: 0, 0.3, 1, or 3 mg/ml. 10/sex/species.

Special Studies

  • Absorption Distribution Metabolism Excretion (Gavage; Topical Application; Intravenous; Gavage; Intravenous; Topical Application)  (S0930)  Completed 
    • Citation: Sipes IG, Knudsen GA, Kuester RK. The effects of dose and route on the toxicokinetics and disposition of 1-butyl-3-methylimidazolium chloride in male F344 rats and female B6C3F1 mice. Drug Metab Dispos. 2008 Feb;36(2):284-93. Epub 2007 Oct 29. Pubmed Abstract
    • Male Rats: F344/N; Female Mice: B6C3F1
    • Dose: 0.5, 5.0, 50 mg/kg [R,M]. 5 mg/kg [R,M].
  • C. elegans  (W05050)  Completed 
    • C. elegans
    • Dose: Feeding: 0, 1, 4, 8, 12, 16, 20, 24, 28, 32, 36, 40 mM. Repro: 0, 4, 8, 16, 24, 32, 40, 48, 56, 64, 72, 80 mM. Growth: 0, 1, 2, 4, 6, 8, 10, 12, 14, 16, 18, 20 mM.

Genetic Toxicology

  • Micronucleus  (G05050)  Completed 
    • Male & Female Sprague Dawley Rats
    • Rats: Harlan Sprague-Dawley
    • Male Negative 
    • Female Negative 
  • Micronucleus  (G05050B)  Completed 
    • Male & Female B6C3F1 Mice
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (A33096)  Completed 
    •  Negative 

Organ Systems Toxicity

  • Immunotoxicity (Topical Application)  (I05050)  Completed 
    • Citation: Frawley RP, Germolec DR, Johnson VJ, Gulledge T, Manheng W, White K Jr, Shockley KR, Harris SF, Hooth M, Ryan K. Evaluation of skin sensitization induced by four ionic liquids. J Appl Toxicol. 2022 Mar;42(3):392-408. https://doi.org/10.1002/jat.4224. Epub 2021 Aug 28.
    • Female Mice: BALB/c
    • Dose: 0, 3.12, 6.25, 12.5 or 25%.