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Testing Status of Gum Guggul Extract M050066


Short-Term Toxicity

  • 13 weeks (Gavage)  (C20605)  Completed 
    • TOX-99 
      Toxicology Studies of A Gum Guggul Extract Formulation Administered by Gavage to Sprague Dawley (Hsd:Sprague Dawley SD) Rats and B6C3F1/N Mice
    • Rats: Harlan Sprague-Dawley; Mice: B6C3F1
    • Dose: Rats: 0, 62.5, 125, 250, 500, or 1000; Mice: 0, 15.5, 31, 62.5, 125, or 250, or mg/kg.

Special Studies

  • Absorption Distribution Metabolism Excretion (in-vitro)  (S0939)  Completed 
    • Human (Cell Lines) [HU]
    • Dose: (in-vitro) 0, 0.3, 1, 10 µM [HU].

Genetic Toxicology

  • Micronucleus  (G05066)  Completed 
    • Rats: Harlan Sprague-Dawley
    • Male Negative 
    • Female Negative 
  • Micronucleus  (G05066B)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 

Organ Systems Toxicity

  • 28 days Immunotoxicity (Gavage)  (IMM20701)  Completed 
    • Female Mice: B6C3F1
    • Dose: 0, 31.25, 62.5, 125, 250, OR 500 MG/KG/DAY.