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Testing Status of Nanoscale material (Fullerene-C60 50 nanometers) M070009

CASRN: 99685-96-8

Formula: C60

Synonyms/Common Names

  • Fullerene-C60 50 nanometers

Short-Term Toxicity

  • 90 days (Inhalation)  (C20407)  Completed 
    • Citation: Sayers BC, Germolec DR, Walker NJ, Shipkowski KA, Stout MD, Cesta MF, Roycroft JH, White KL, Baker GL, Dill JA, Smith MJ. Respiratory toxicity and immunotoxicity evaluations of microparticle and nanoparticle C60 fullerene aggregates in mice and rats following nose-only inhalation for 13 weeks. Nanotoxicology. 2016 Dec;10(10):1458-1468. Epub 2016 Sep 30. https://doi.org/10.1080/17435390.2016.1235737
    • Citation: Sayers BC, Walker NJ, Roycroft JH, Germolec DR, Baker GL, Clark ML, Hayden BK, DeFord H, Dill JA, Gupta A, Stout MD. Lung deposition and clearance of microparticle and nanoparticle C60 fullerene aggregates in B6C3F1 mice and Wistar Han rats following nose-only inhalation for 13 weeks. Toxicology. 2016 Jan;339:87-96. Epub 2015 Dec 2. https://doi.org/10.1016/j.tox.2015.11.003.
    • TOX-87 (NIH Number: 2378-8992)
      Toxicity Studies of Fullerene C60 (1μm and 50 nm) (CASRN 99685-96-8) Administered by Nose-Only Inhalation to Wistar Han [Crl:WI (Han)] Rats and B6C3F1/N Mice
    • Rats: Wistar Han; Mice: B6C3F1
    • Dose: R&M: 0, 0.5, or 2.0 mg/m3; 34 sex/species/group.

Genetic Toxicology

  • Micronucleus  (G07009)  Completed 
    • Rats: Wistar Han
    • Male Negative 
    • Female Negative 
  • Micronucleus  (G07009B)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 

Organ Systems Toxicity

  • Immunotoxicity (Inhalation)  (I20407)  Completed 
    • Citation: Sayers BC, Germolec DR, Walker NJ, Shipkowski KA, Stout MD, Cesta MF, Roycroft JH, White KL, Baker GL, Dill JA, Smith MJ. Respiratory toxicity and immunotoxicity evaluations of microparticle and nanoparticle C60 fullerene aggregates in mice and rats following nose-only inhalation for 13 weeks. Nanotoxicology. 2016 Dec;10(10):1458-1468. Epub 2016 Sep 30. https://doi.org/10.1080/17435390.2016.1235737
    • Citation: Sayers BC, Walker NJ, Roycroft JH, Germolec DR, Baker GL, Clark ML, Hayden BK, DeFord H, Dill JA, Gupta A, Stout MD. Lung deposition and clearance of microparticle and nanoparticle C60 fullerene aggregates in B6C3F1 mice and Wistar Han rats following nose-only inhalation for 13 weeks. Toxicology. 2016 Jan;339:87-96. Epub 2015 Dec 2. https://doi.org/10.1016/j.tox.2015.11.003.
    • Male and Female Rats: Wistar Han
    • Dose: 0, 0.5, or 2 mg/m3.
  • Immunotoxicity (Inhalation)  (I20407B)  Completed 
    • Citation: Sayers BC, Germolec DR, Walker NJ, Shipkowski KA, Stout MD, Cesta MF, Roycroft JH, White KL, Baker GL, Dill JA, Smith MJ. Respiratory toxicity and immunotoxicity evaluations of microparticle and nanoparticle C60 fullerene aggregates in mice and rats following nose-only inhalation for 13 weeks. Nanotoxicology. 2016 Dec;10(10):1458-1468. Epub 2016 Sep 30. https://doi.org/10.1080/17435390.2016.1235737
    • Citation: Sayers BC, Walker NJ, Roycroft JH, Germolec DR, Baker GL, Clark ML, Hayden BK, DeFord H, Dill JA, Gupta A, Stout MD. Lung deposition and clearance of microparticle and nanoparticle C60 fullerene aggregates in B6C3F1 mice and Wistar Han rats following nose-only inhalation for 13 weeks. Toxicology. 2016 Jan;339:87-96. Epub 2015 Dec 2. https://doi.org/10.1016/j.tox.2015.11.003.
    • Male and Female Mice: B6C3F1/N
    • Dose: 0, 0.5, or 2 mg/m3.