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Testing Status of Dimethylethanolamine (DMAE) M200084

CASRN: 108-01-0

Formula: C4-H11-N-O

Synonyms/Common Names

  • Deanol
  • Dimethylaminoethanol
  • DMAE
  • Ethanolamine
  • Ethanol, 2-(dimethylamino)-
  • N,N-Dimethylethanolamine

Special Studies

  • Absorption Distribution Metabolism Excretion (Gavage)  (K20084)  Completed 
    • Citation: Shipkowski KA, Sanders JM, McDonald JD, Garner CE, Doyle-Eisele M, Wegerski CJ, Waidyanatha S. Comparative disposition of dimethylaminoethanol and choline in rats and mice following oral or intravenous administration. Toxicol Appl Pharmacol. 2019 Sep 1;378:114592. doi: https://doi.org/10.1016/j.taap.2019.05.011. Epub 2019 May 14.Pubmed Abstract
    • Male and Female Rats [R]: Wistar Han; Male and Female Mice [M]: B6C3F1
    • Dose: (gavage) 10, 100, 500 mg/kg [R,M].

Genetic Toxicology

  • Drosophila  (345686)  Completed 
    • Citation: Foureman P, Mason JM, Valencia R, Zimmering S. Chemical mutagenesis testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ Mol Mutagen. 1994;23(1):51-63. doi: 10.1002/em.2850230109
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Salmonella  (990909)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Equivocal 
  • Salmonella  (994377)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative