Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of Diazoaminobenzene M20124

CASRN: 136-35-6

Formula: C12-H11-N3

Synonyms/Common Names

  • DAAB
  • 1-Triazene, 1,3-diphenyl-

Short-Term Toxicity

  • 2 weeks (Topical Application)  (C96002)  Completed 
    • TOX-73 (NIH Number: 02-4412)
      Metabolism, Toxicity, and Predicted Carcinogenicity Studies of Diazoaminobenzene (CASRN 136-35-6) Administered Dermally to F344/N Rats and B6C3F1 Mice
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 12.5, 25, 50, 100, OR 200 MG/KG B.W..

Special Studies

  • Toxicokinetic Study (Dosed-Feed)  (S0638)  Completed 
    • Male Rats [R]: F344/N; Male Mice [M]: B6C3F1
    • Dose: (gavage) 20 mg/kg. (dermal) 2, 20 mg/cm2. (intravenous) 2 mg/kg [R,M].

Genetic Toxicology

  • Micronucleus  (A64807)  Completed 
    • Citation: Ress NB, Witt KL, Xu J, Haseman JK, Bucher JR. Micronucleus induction in mice exposed to diazoaminobenzene or its metabolites, benzene and aniline: implications for diazoaminobenzene carcinogenicity. Mutat Res. 2002 Nov 26;521(1-2):201-8. doi: 10.1016/s1383-5718(02)00241-3
    • Mice: B6C3F1
    • Male Positive 
  • Micronucleus  (A72640)  Completed 
    • Citation: Ress NB, Witt KL, Xu J, Haseman JK, Bucher JR. Micronucleus induction in mice exposed to diazoaminobenzene or its metabolites, benzene and aniline: implications for diazoaminobenzene carcinogenicity. Mutat Res. 2002 Nov 26;521(1-2):201-8. doi: 10.1016/s1383-5718(02)00241-3
    • Mice: B6C3F1
    • Male Positive 
  • Salmonella  (529702)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Positive 

in vitro Testing

  • Bovine Corneal Opacity and Premeability Assay (Gavage)  (IVT20003A)  Completed 
    • Mice: B6C3F1
  • Dose-Response Cytotoxicity Assay Using the EpiDermTM Skin Model (Gavage)  (IVT20003B)  Completed 
    • Mice: B6C3F1
  • Alternate (Intravenous)  (IVT20003B)   
    • Rats: F344/N
  • Neutral Red Uptake Bioassay (Gavage)  (IVT20003C)  Completed 
    • Mice: B6C3F1/N; Rats: F344/N
  • Alternate (Dosed-Feed)  (IVT20003D)   
    • Mice: B6C3F1
  • Cytotoxicity Assay Using MTT Reduction in Primary Rat Hepatocytes (Dosed-Feed)  (IVT20003D)  Completed 
    • Rats: F344/N