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Testing Status of trans-Cinnamaldehyde M88146

CASRN: 14371-10-9

Formula: C9-H8-O

Synonyms/Common Names

  • 2-Propenal, 3-phenyl-, (E)- (9CI)

Short-Term Toxicity

  • 2 weeks (Gavage)  (C56111E)  Completed 
    • Rats: F344/N
    • Dose: FEMALE RATS ONLY: 0, 235, 470, 940, 1410 MG/KG/DAY.
  • 13 weeks (Microencapsulation in Feed)  (C56111B)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 0.41, 0.82, 1.65 OR 3.30% OR 4100, 8200, 16500 OR 33000 PPM; 10/SEX/DOSE.

Long-Term Carcinogenicity

  • 2 years (Microencapsulation in Feed)  (C56111B)  Completed 
    • TR-514 (NIH Number: 04-4448)  (Peer Review Approval 09/05/2002A )
      Toxicology and Carcinogenesis Studies of trans-Cinnamaldehyde (Microencapsulated) (CASRN 14381-10-9) in F344/N Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0 (UNTREATED), 0 (VEHICLE), 1, 000, 2, 100, or 4, 100 ppm; 50/SEX/DOSE (equivalent to 0.1%, 0.21%, or 0.41%). R&M: 0 (UNTREATED), 0 (VEHICLE), 1, 000, 2, 100, or 4, 100 ppm; 50/SEX/DOSE (equivalent to 0.1%, 0.21%, or 0.41%).
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 

Genetic Toxicology

  • Drosophila  (896321)  Completed 
    • Citation: Woodruff RC, Mason JM, Valencia R, Zimmering S. Chemical mutagenesis testing in Drosophila. V. Results of 53 coded compounds tested for the National Toxicology Program. Environ Mutagen. 1985;7(5):677-702. doi: 10.1002/em.2860070507
    • Sex-Linked Recessive Lethal Positive 
    • Reciprocal Translocation Negative 
  • In Vitro Cytogenetics (CA/SCE)  (290481)  Completed 
    • Citation: Galloway SM, Armstrong MJ, Reuben C, Colman S, Brown B, Cannon C, Bloom AD, Nakamura F, Ahmed M, Duk S, Rimpo J, Margolin B, Resnick M, Anderson B, and Zeiger E. Chromosome aberrations and sister chromatid exchanges in Chinese hamster ovary cells: evaluations of 108 chemicals. Environ Mol Mutagen. 1987;10 Suppl 10:1-175. doi: 10.1002/em.2850100502
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Micronucleus  (A19689)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Micronucleus  (B19689)  Completed 
    • Mice: B6C3F1
    • Male Equivocal 
    • Female Negative 
  • Salmonella  (579971)  Completed 
    •  Weakly Positive 
  • Salmonella  (816373)  Completed 
    • Citation: Mortelmans K, Haworth S, Lawlor T, Speck W, Tainer B, Zeiger E. Salmonella mutagenicity tests: II. Results from the testing of 270 chemicals. Environ Mutagen. 1986;8 Suppl 7:1-119
    •  Negative