Testing Status of Pesticide/fertilizer contamination--mixture 3 M890016

CASRN: PESTFERTMIX3

Synonyms/Common Names

• Iowa mixture

Secondary:

• 15972-60-8 - Alachlor
• 6484-52-2 - Ammonium nitrate
• 1912-24-9 - Atrazine
• 21725-46-2 - Cyanazine
• 51218-45-2 - Metolachlor
• 21087-64-9 - Metribuzin

Short-Term Toxicity

• 26 weeks (Dosed-Water)  (C89010)  Completed 
  • TOX-36 (NIH Number: 93-3385)
    Toxicity Studies of Pesticide/Fertilizer Mixtures Administered in Drinking Water to F344/N Rats and B6C3F1 Mice
  • Rats: F344/N; Mice: B6C3F1
  • Dose: RATS AND MICE (0, 0.1X, 1X, 10X, OR 100X); RATS 40/GROUP, MICE 30/GROUP.

Genetic Toxicology

• Micronucleus  (A48542)  Completed 
  • Mice: MICE
  • Female Positive (Nonstandard Protocol) 

Organ Systems Toxicity

• Continuous Breeding (Legacy) (Dosed-Water)  (RACB90029)  Completed 
  • Citation: Heindel JJ, Chapin RE, Gulati DK, George JD, Price CJ, Marr MC, Myers CB, Barnes LH, Fail PA, Grizzle TB, Schwetz BA, and Yang RSH. Assessment of the Reproductive and Developmental Toxicity of Pesticide/Fertilizer Mixtures Based on Confirmed Pesticide Contamination in California and Iowa Groundwater. Fund. Appl. Toxicol. 22:605-621 (1994).
  • Male and Female Mice: Swiss
  • Dose: N/A; 0, 1, 10, 100 X; N/A; 0, 100 X.
• 6 to 20 GD Conventional Teratology (Dosed-Water)  (TER91032)  Completed 
  • Citation: Heindel JJ, Chapin RE, Gulati DK, George JD, Price CJ, Marr MC, Myers CB, Barnes LH, Fail PA, Grizzle TB, Schwetz BA, and Yang RSH. Assessment of the Reproductive and Developmental Toxicity of Pesticide/Fertilizer Mixtures Based on Confirmed Pesticide Contamination in California and Iowa Groundwater. Fund. Appl. Toxicol. 22:605-621 (1994).
  • Rats: Sprague Dawley
  • Rats Maternal Negative 
  • Rats Fetal Negative 
  • Dose: 0X, 1X, 10X, AND 100X.