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Testing Status of Chlorpyrifos M90011

CASRN: 2921-88-2

Formula: C9-H11-Cl3-N-O3-P-S

Synonyms/Common Names

  • Brodan
  • Dowco 179
  • Dursban
  • ENT 27311
  • Killmaster
  • Lorsban
  • Phosphorothioic acid, O,O-diethyl O-(3,5,6-trichloro-2-pyridinyl) ester
  • Pyrinex
  • Spannit
  • Suscon
  • Trichlorpyrphos

Planned Carcinogenicity/Toxicity

  • 1 day (Gavage) Selected (C90011B)  
    • Series Dose Escalation Cardiovascular Functional Assessment Study
    • Rats: Hsd:Sprague Dawley SD
    • Dose: Dose escalation, Single dose + recovery per dose level 0, 0.1, 0.3, 1, 3, 10 mg/kg.

Short-Term Toxicity

  • 14 days (Gavage)  (C90011)  On Test 
    • Rats: Hsd:Sprague Dawley SD
    • Dose: 0, 0.1, 0.3, 1, 3, 10 mg/kg.

Special Studies

  • C. elegans  (S0864)  Completed 
    • Citation: Behl M, Rice JR, Smith MV, Co CA, Bridge M, Hsieh JH, Freedman JH, Boyd WA. Comparative toxicity of organophosphate flame retardants and polybrominated diphenyl ethers to c. Elegans. Toxicol Sci. 2016 Aug;154(2):241-252Pubmed Abstract
    • C. elegans [CE]
    • Dose: feed (.42, .53, .67, .87, 1.07, 1.33, 1.67, 2.13, 2.67, 3.33, 4.20 mM) 06/14/06. repro (0.01, 0.016, 0.025, 0.04, 0.063, 0.1, 0.16, 0.25, 0.4, 0.63, 1.0 mM) 10/25/04. growth (3.2, 4.0, 5.0, 6.3, 7.9, 10, 12.6, 16, 20, 25, 32 mM) 04/25/06.
  • Toxicokinetic Study (Gavage; Intravenous; Gavage; Intravenous)  (S0321)  Completed 
    • Male and Female Rats [R]: F344/N; Male and Female Mice [M]: B6C3F1
    • Dose: (gavage) 3, 9, 30 mg/kg [R,M]. (intravenous) 3 mg/kg, Chlopyrifos 1.66 mg/kg; 3,5,6-Trichloro-2-pyridinol [R,M].

Genetic Toxicology

  • Salmonella  (A83234)  Completed 
    •  Negative 

Organ Systems Toxicity

  • in-life phase conducted between Februrary 1, 1993 and March 10, 1993 Immunotoxicity (Topical Application)  (IMM95001)  Completed 
    • Female Mice: B6C3F1
    • Dose: 0.3, 1.0 & 3.0% IN ACETONE (99.8%) FOR SENSITIZATION, & 3.0% FOR CHALLENGE IN COMBINED MEST & LLNA & 1.0% & 3.0% IN THE LLNA ALONE. DNFB WAS USED AS THE POSITIVE CONTROL AT A CONCENTRATION OF 0.25% FOR SENSITIZATION & 0.5% FOR CHALLENGE..
    • Mice Female  NOT A SENSITIZER
    • NOT A SENSITIZER
  • 14 GD - PND42 Juvenile Pesticide Assessment (Gavage)  (JPA96001)  Completed 
    • Male and Female Rats: Sprague Dawley
    • Dose: 0, 2.5, 3.0, OR 5.0 MG/KG/DAY.