Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of Propylene glycol mono-t-butyl ether M90029

CASRN: 57018-52-7

Formula: C7-H16-O2

Synonyms/Common Names

  • 1-(1,1-Dimethylethoxy)-2-propanol (9CI)
  • PGMBE
  • PGTBE
  • Propylene glycol t-butyl ether
  • tert-Butoxypropanol

Short-Term Toxicity

  • 2 weeks (Inhalation)  (C90004)  Completed 
    • Rats: F344/N; Rats: NCI Black Reiter (NBR); Mice: B6C3F1
    • Dose: R&M: 0, 75, 150, 300, 600, OR 1200 PPM; 5/SEX/SPECIES/GROUP.
  • 13 weeks (Inhalation)  (C90004)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 75, 150, 300, 600, OR 1200 PPM; 20/SEX/GROUP M: 0, 75, 150, 300, 600, OR 1200 PPM; 10/SEX/GROUP.

Long-Term Carcinogenicity

  • 2 years (Inhalation)  (C90004)  Completed 
    • TR-515 (NIH Number: 04-4449)  (Peer Review Approval 05/22/2003A )
      Toxicology and Carcinogenesis Studies of Propylene Glycol Mono-t-Butyl Ether (CASRN 57018-52-7) in F344/N Rats and B6C3F1 Mice and a Toxicology Study of Propylene Glycol Mono-t-Butyl Ether In Male NBR Rats (Inhalation Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 75, 300, OR 1200 PPM; 50/SEX/SPECIES/GROUP.
    • Carcinogenesis Results
      • Male Rats Equivocal Evidence 
      • Female Rats No Evidence 
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 

Special Studies

  • Absorption Distribution Metabolism Excretion (Gavage)  (S0179)  Completed 
    • Male Rats [R]: F344/N
    • Dose: (gavage) 377.1, 37.71, 3.77 mg/kg [R].
  • Toxicokinetic Study (Inhalation)  (K90004)  Completed 
    • Male and Female Rats [R]: F344/N; Male and Female Mice [M]: B6C3F1
    • Dose: (inhalation) 75, 300, or 1200 ppm (single administration, 6 hrs.) [R]. (inhalation) 75, 300, or 1200 ppm (single administration, 6 hrs.) [M].

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (911469)  Completed 
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Micronucleus  (A04540)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Weakly Positive 
  • Salmonella  (A40505)  Completed 
    •  Positive