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Testing Status of 2,3,4,7,8-Pentachlorodibenzofuran M920005

CASRN: 57117-31-4

Formula: C12-H3-Cl5-O

Synonyms/Common Names

  • Dibenzofuran, 2,3,4,7,8-pentachloro-

Special Studies

  • Absorption Distribution Metabolism Excretion (Intravenous; Topical Application)  (S0518)  Completed 
    • Citation: Brewster DW, Elwell MR, Birnbaum LS. Toxicity and disposition of 2,3,4,7,8-pentachlorodibenzofuran (4PeCDF) in the rhesus monkey (Macaca mulatta). Toxicol Appl Pharmacol. 1988 Apr;93(2):231-46.Pubmed Abstract
    • Monkeys [MO]: Rhesus
    • Dose: (intravenous) 34 ug/kg [MO]. (topical application) 34 ug/kg [MO].
  • Absorption Distribution Metabolism Excretion (Gavage; Inhalation)  (S0519)  Completed 
    • Citation: Brewster DW, Birnbaum LS. Disposition and excretion of 2,3,4,7,8-pentachlorodibenzofuran in the rat. Toxicol Appl Pharmacol. 1987 Sep 15;90(2):243-52.Pubmed Abstract
    • Male Rats [R]: F344/N
    • Dose: (gavage) 34, 170, 340 ug/kg [R]. (inhalation) 34 ug/kg [R].
  • Absorption Distribution Metabolism Excretion (Gavage; Topical Application; Intravenous)  (S0764)  Completed 
    • Citation: Brewster DW, Banks YB, Clark AM, Birnbaum LS. Comparative dermal absorption of 2,3,7,8-tetrachlorodibenzo-p-dioxin and three polychlorinated dibenzofurans. Toxicol Appl Pharmacol. 1989 Jan;97(1):156-66.Pubmed Abstract
    • Male Rats [R]: F344/N
    • Dose: (topical application) 34, 170, 340 ug/kg [R].
  • Toxicokinetic Study (Gavage)  (S0623)  Completed 
    • Female Rats [R]: Sprague Dawley
    • Dose: (gavage) 6, 200 ng/kg [R].

Organ Systems Toxicity

  • Conventional Teratology (Gavage)  (TER86102)  Completed 
    • Mice: C57BL/6
    • Dose: 0, .001, .003, .01, .02, .03, .04, .06, .08 MG/KG.
    • Mice Maternal Positive 
    • Mice Fetal Positive 
  • Single dose Immunotoxicity (Gavage)  (I92005)  Completed 
    • Female Mice: B6C3F1
    • Dose: 0, 3, 9, 15, 30 and 90 ug/kg.

Toxicogenomics

  • Microarray Analysis  (T92005)  Completed