Testing Status of p-tert-Butylcatechol M930033

CASRN: 98-29-3

Formula: C10-H14-O2

Synonyms/Common Names

• 1,2-Benzenediol, 4-(1,1-dimethylethyl)-
• 1,2-Dihydroxy-4-tert-butylbenzene
• Pyrocatechol, 4-tert-butyl-
• TBC
• 4-tert-Butyl-1,2-dihydroxybenzene

Short-Term Toxicity

• 2 weeks (Dosed-Feed)  (C93011)  Completed 
  • TOX-70 (NIH Number: 00-4415)
    Toxicity Studies of p-tert-Butylcatechol (CASRN 98-29-3) Administered in Feed to F344/N Rats and B6C3F1 Mice
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R&M: 0, 3125, 6250, 12500, 25000, OR 50000 PPM; 5/SEX/DOSE.
• 13 weeks (Dosed-Feed)  (C93011B)  Completed 
  • TOX-70 (NIH Number: 00-4415)  (Tox Peer Review 03/11/2002A )
    Toxicity Studies of p-tert-Butylcatechol (CASRN 98-29-3) Administered in Feed to F344/N Rats and B6C3F1 Mice
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R&M: 0, 781, 1562, 3125, 6250, OR 12, 500 PPM; 10/SPECIES/GROUP.

Special Studies

• Absorption Distribution Metabolism Excretion (Gavage; Topical Application; Intravenous; Gavage; Topical Application; Intravenous)  (S0556)  Completed 
  • Male Rats [R]: F344/N; Male Mice [M]: B6C3F1
  • Dose: (gavage) 2, 200, 1000 mg/kg [R]. (topical application) 0.6, 6.0, 63 mg/kg [R]. (intravenous) 3 mg/kg [R,M]. (gavage) 300 mg/kg [M]. (topical application) 0.04, 4 mg [M].

Genetic Toxicology

• Micronucleus  (A09151)  Completed 
  • Rats: Fischer 344
  • Male Negative 
• Micronucleus  (A14992)  Completed 
  • Mice: B6C3F1
  • Male Negative 
  • Female Negative 
• Salmonella  (A39963)  Completed 
  •  Negative