Testing Status of Diisopropylcarbodiimide M930063
CASRN: 693-13-0
Formula: C7-H14-N2
Synonyms/Common Names
- DIC
- 1,3-Diisopropylcarbodiimide
- N,N'-Diisopropylcarbodiimide
Short-Term Toxicity
- 2 weeks (Topical Application)
(C93020)
Completed
- Rats: F344/N; Mice: B6C3F1
- Dose: R&M: 0, 10, 30, 90, 269, OR 806 MG/ML; 5/SEX/SPECIES/GROUP.
- 20 weeks (Topical Application)
(C93020B)
Completed
- GMM-10 (NIH Number: 07-4427)
(Peer Review Approval 09/28/2005A )
Toxicology Study of Diispropylcarbodiimide (CASRN 693-13-0) in Genetically Modified (FVB Tg.AC Hemizygous) Mice and Carcinogenicity Study of Diispropylcarbodiimide in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient Mice (Dermal Studies) - Mice: Tg.AC (FVB/N) Hemizygous
- Dose: FEMALE MICE: 0, 4.38, 8.75, 17.5, 35, OR 70 MG/KG; 10/GROUP.
- Carcinogenesis Results
- Female No Evidence
- GMM-10 (NIH Number: 07-4427)
(Peer Review Approval 09/28/2005A )
- 27 weeks (Topical Application)
(C93020C)
Completed
- GMM-10 (NIH Number: 07-4427)
(Peer Review Approval 09/28/2005A )
Toxicology Study of Diispropylcarbodiimide (CASRN 693-13-0) in Genetically Modified (FVB Tg.AC Hemizygous) Mice and Carcinogenicity Study of Diispropylcarbodiimide in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient Mice (Dermal Studies) - Mice: P53 +/- (C57BL/6)
- Dose: FEMALE MICE: 0, 4.38, 8.75, 17.5, 35, OR 70 MG/KG; 15/GROUP.
- Carcinogenesis Results
- Female No Evidence
- GMM-10 (NIH Number: 07-4427)
(Peer Review Approval 09/28/2005A )
- 13 weeks (Topical Application)
(C93020)
Completed
- Rats: F344/N; Mice: B6C3F1
- Dose: R: 0, 10, 20, 40, 80, OR 160 MG/KG M: 0, 17.5, 35, 70, 140, OR 280 10 SEX/SPECIES/GROUP, 6 GROUPS.
Long-Term Carcinogenicity
- 2 years (Topical Application)
(C93020D)
Completed
- TR-523 (NIH Number: 07-4473)
(Peer Review Approval 09/28/2005A )
Toxicology and Carcinogenesis Studies of Diisopropylcarbodiimide (CASRN 693-13-0) in F344/N Rats and B6C3F1 Mice (Dermal Studies) - Rats: F344/N; Mice: B6C3F1
- Dose: R&M: 0, 10, 20, OR 40 MG/KG; 50/SEX/SPECIES.
- Carcinogenesis Results
- Male Rats No Evidence
- Female Rats No Evidence
- Male Mice No Evidence
- Female Mice No Evidence
- TR-523 (NIH Number: 07-4473)
(Peer Review Approval 09/28/2005A )
Special Studies
- Absorption Distribution Metabolism Excretion (Topical Application; Intravenous; Topical Application)
(S0662)
Completed
- Male Rats [R]: F344/N; Male Mice [M]: B6C3F1
- Dose: (topical application) 3.9, 4.1, 40.9 mg/kg [R]. (intravenous) 7.6, 7.8 mg/kg [M]. (topical application) 6.9 mg/kg [M].
Genetic Toxicology
- Micronucleus
(A04322)
Completed
- Citation: Witt KL, Tice RR, Shelby MD, Chhabra RS, Zeiger E. Induction of micronucleated erythrocytes in rodents by diisopropylcarbodiimide and dicyclohexylcarbodiimide: dependence on exposure protocol. Environ Mol Mutagen. 1999;33(1):65-74. doi: 10.1002/(sici)1098-2280(1999)33:1<65::aid-em8>3.0.co;2-7
- Mice: B6C3F1
- Male Equivocal
- Micronucleus
(A22799)
Completed
- Citation: Witt KL, Tice RR, Shelby MD, Chhabra RS, Zeiger E. Induction of micronucleated erythrocytes in rodents by diisopropylcarbodiimide and dicyclohexylcarbodiimide: dependence on exposure protocol. Environ Mol Mutagen. 1999;33(1):65-74. doi: 10.1002/(sici)1098-2280(1999)33:1<65::aid-em8>3.0.co;2-7
- Mice: B6C3F1
- Male Positive
- Female Positive
- Micronucleus
(A55884)
Completed
- Citation: Witt KL, Tice RR, Shelby MD, Chhabra RS, Zeiger E. Induction of micronucleated erythrocytes in rodents by diisopropylcarbodiimide and dicyclohexylcarbodiimide: dependence on exposure protocol. Environ Mol Mutagen. 1999;33(1):65-74. doi: 10.1002/(sici)1098-2280(1999)33:1<65::aid-em8>3.0.co;2-7
- Mice: B6C3F1
- Male Positive
- Micronucleus
(A76999)
Completed
- Citation: Witt KL, Tice RR, Shelby MD, Chhabra RS, Zeiger E. Induction of micronucleated erythrocytes in rodents by diisopropylcarbodiimide and dicyclohexylcarbodiimide: dependence on exposure protocol. Environ Mol Mutagen. 1999;33(1):65-74. doi: 10.1002/(sici)1098-2280(1999)33:1<65::aid-em8>3.0.co;2-7
- Rats: Fischer 344
- Male Negative
- Salmonella
(A69920)
Completed
- Equivocal
- Salmonella
(A92772)
Completed
- Negative
Organ Systems Toxicity
- 4 days Immunotoxicity (Topical Application)
(IMM95010)
Completed
- Female Mice: B6C3F1
- Dose: .03, .15, .3, 1.5, AND 3% DIC IN ACETONE (99.8%) FOR SENSIZATION, AND 10% DIC FOR CHALLENGE IN THE MEST AND 1.5, 3 AND 10% DIC IN THE LLNA. .25% DNFB USED AS POSITIVE CONTROL FOR SENSITIZATION, AND .5% FOR CHALLENGE..